RESEARCH PROGRESS ON FERROPTOSIS AND ITS ROLE IN EPILEPSY

被引：8

作者：

Liu, X. ^{[1
]}

Chen, J. ^{[1
]}

机构：

[1] Jiangnan Univ, Dept Paediat, Med Ctr, Wuxi 2 Peoples Hosp, Wuxi, Jiangsu, Peoples R China

来源：

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2022年 / 73卷 / 06期

关键词：

ferroptosis; epilepsy; glutathione; glutathione peroxidase; lipid peroxide; iron metabolism; coenzyme Q10 oxidoreductase; reactive oxygen species; oxidative stress; LIPID-PEROXIDATION; CELL-DEATH; DISEASE RELEVANCE; IRON; MECHANISMS; CANCER; INHIBITION; METABOLISM; REGULATOR; ERASTIN;

D O I：

10.26402/jpp.2022.6.02

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Epilepsy is a disease characterized by central nervous system dysfunction induced by an excessive synchronous discharge of cerebral neurons, with diverse etiologies and complicated pathogenesis, and is difficult to treat. Ferroptosis is a newly defined iron-dependent programmed cell death, characterized by excessive accumulation of lipid peroxides and reactive oxygen species. Studies have shown that ferroptosis is involved in the occurrence and development of epilepsy, and this has become a research focus. In this article, we review and summarize the following aspects: the outline of ferroptosis, the mechanisms of ferroptosis, and the role of ferroptosis in epilepsy, which provide a reference for further exploration of the pathophysiological mechanisms of epilepsy and search of novel therapeutic targets.

引用

页码：699 / 706

页数：8

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