Ulcerative Colitis: Ultrastructure of Interstitial Cells in Myenteric Plexus

被引：16

作者：

Rumessen, J. J. ^{[1
]}

Vanderwinden, J. -M.

Horn, T.

机构：

[1] Gentofte Univ Hosp, Dept Gastroenterol F, DK-2900 Hellerup, Denmark

来源：

ULTRASTRUCTURAL PATHOLOGY | 2010年 / 34卷 / 05期

关键词：

MACROPHAGE-LIKE CELLS; INFLAMMATORY-BOWEL-DISEASE; SLOW-TRANSIT CONSTIPATION; DEEP MUSCULAR PLEXUS; RESIDENT MACROPHAGES; SUBMUCOSAL BORDER; NERVOUS-SYSTEM; MUSCLE-CELLS; HUMAN COLON; CAJAL;

D O I：

10.3109/01913121003770701

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

Interstitial cells of Cajal (ICC) are key regulatory cells in the gut. In the colon of patients with severe ulcerative colitis (UC), myenteric ICC had myoid ultrastructural features and were in close contact with nerve terminals. In all patients as opposed to controls, some ICC profiles showed degenerative changes, such as lipid droplets and irregular vacuoles. Nerve terminals often appeared swollen and empty. Glial cells, muscle cells, and fibroblast-like cells (FLC) showed no alterations. FLC enclosed macrophages (MLC), which were in close contact with naked axon terminals. The organization and cytological changes may be of pathophysiological significance in patients with UC.</.

引用

页码：279 / 287

页数：9

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