Release-controlled curcumin proliposome produced by ultrasound-assisted supercritical antisolvent method

被引：27

作者：

Jia, Jingfu ^{[1
]}

Song, Ningning ^{[1
]}

Gai, Yanzhe ^{[1
]}

Zhang, Lin ^{[1
]}

Zhao, Yaping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2016年 / 113卷

基金：

中国国家自然科学基金;

关键词：

Supercritical antisolvent; Ultrasound; Proliposome; Curcumin; LIPOSOME-ENCAPSULATED CURCUMIN; IN-VITRO; DRUG-DELIVERY; BIOAVAILABILITY; PRECIPITATION; MORPHOLOGY; ACID; SIZE; OIL;

D O I：

10.1016/j.supflu.2016.03.026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Curcumin proliposome (CPL) was prepared using supercritical antisolvent technique assisted with ultrasound. The effects of the process parameters, such as weight ratio of starting material, pressure, temperature, and ultrasound power, on the entrapment efficiency (EE) and the drug loads were investigated. The latter three parameters were optimized using response surface methodology in terms of their effects on EE. The morphology and structure of the generated CPL were characterized by SEM, XRD and DSC. The in vitro release of the curcumin proliposome (CL) formed via hydration of the CPL was studied. The results indicated that the release of the curcumin could be controlled by manipulating the morphology of the CPL including the precipitation form of the starting materials, the particle size, and the particle fusion. The CPL was stable for at least 3 months at low temperature storage. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：150 / 157

页数：8

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