Three-dimensional bioactive and biodegradable scaffolds fabricated by surface-selective laser sintering

被引:95
作者
Antonov, EN
Bagratashvili, VN
Whitaker, MJ
Barry, JJA
Shakesheff, KM
Konovalov, AN
Popov, VK
Howdle, SM
机构
[1] Russian Acad Sci, Inst Laser & Informat Technol, Troitsk 142092, Moscow Region, Russia
[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England
[3] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
基金
英国惠康基金;
关键词
D O I
10.1002/adma.200400838
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Surface-selective laser sintering (SSLS) has been developed for fabrication of three-dimensional polymer composite scaffolds with precise dimensions and intricate structure (see Figure), which are bioactive and biodegradable. SSLS allows sintering of polymer powders by melting only the surface layers of particles, which prevents overheating of internal domains, allowing incorporation of bioactive molecules into the structures.
引用
收藏
页码:327 / +
页数:5
相关论文
共 18 条
[1]  
ANTONOV AV, 1998, OPT REKH, V13, P55
[2]   Enzymatic activity of alkaline phosphatase inside protein and polymer structures fabricated via multiphoton excitation [J].
Basu, S ;
Campagnola, PJ .
BIOMACROMOLECULES, 2004, 5 (02) :572-579
[3]   SPECTROPHOTOMETRIC ASSAY OF BOVINE PANCREATIC RIBONUCLEASE BY THE USE OF CYTIDINE 2'-3'-PHOSPHATE [J].
CROOK, EM ;
MATHIAS, AP ;
RABIN, BR .
BIOCHEMICAL JOURNAL, 1960, 74 :234-238
[4]   Enhanced functions of osteoblasts on nanometer diameter carbon fibers [J].
Elias, KL ;
Price, RL ;
Webster, TJ .
BIOMATERIALS, 2002, 23 (15) :3279-3287
[5]   Protein stability in controlled-release systems [J].
Fu, K ;
Klibanov, AM ;
Langer, R .
NATURE BIOTECHNOLOGY, 2000, 18 (01) :24-25
[6]   Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials [J].
Howdle, SM ;
Watson, MS ;
Whitaker, MJ ;
Popov, VK ;
Davies, MC ;
Mandel, FS ;
Wang, JD ;
Shakesheff, KM .
CHEMICAL COMMUNICATIONS, 2001, (01) :109-110
[7]   Scaffolds in tissue engineering bone and cartilage [J].
Hutmacher, DW .
BIOMATERIALS, 2000, 21 (24) :2529-2543
[8]   Effects of morphology, conformation and configuration on the IR and Raman spectra of various poly(lactic acid)s [J].
Kister, G ;
Cassanas, G ;
Vert, M .
POLYMER, 1998, 39 (02) :267-273
[9]   Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering [J].
Landers, R ;
Hübner, U ;
Schmelzeisen, R ;
Mülhaupt, R .
BIOMATERIALS, 2002, 23 (23) :4437-4447
[10]   Dual material rapid prototyping techniques for the development of biomedical devices. Part 1: Space creation [J].
Liew, CL ;
Leong, KF ;
Chua, CK ;
Du, Z .
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2001, 18 (10) :717-723