Human Leukocyte Antigen-Disease Associations in Rheumatoid Arthritis

被引：95

作者：

van Drongelen, Vincent ^{[1
]}

Holoshitz, Joseph ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, 1150 West Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 03期

关键词：

HLA; Rheumatoid arthritis; Autoimmunity; Shared epitope; HLA-DRB1 SHARED EPITOPE; GENE-ENVIRONMENT INTERACTION; MOLECULAR-BASIS; HISTOCOMPATIBILITY ANTIGENS; AUTOIMMUNE-DISEASES; HLA; SUSCEPTIBILITY; ANTIBODIES; SMOKING; AUTOANTIBODIES;

D O I：

10.1016/j.rdc.2017.04.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cause and pathogenesis of rheumatoid arthritis (RA) are influenced by environmental and genetic risk factors. Shared epitope-coding human leukocyte antigen (HLA)-DRB1 alleles increase RA risk and severity; however, the underlying mechanisms of action remain unclear. In contrast, several other DRB1 alleles protect against RA. Additionally, genome-wide association studies suggest that RA associates with other, HLA and non-HLA, genes; but the relative contributions of such risk loci to RA are incompletely understood. Future research challenges include integrating the epidemiologic and genomic data into validated arthritogenic pathways and determining the mechanisms of interaction between RA risk genes and environmental influences.

引用

页码：363 / +

页数：15

共 110 条

[1] Use of autoantigen-knockout mice in developing an active disease model for pemphigus [J].

Amagai, M ;

Tsunoda, K ;

Suzuki, H ;

Nishifuji, K ;

Koyasu, S ;

Nishikawa, T .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (05) :625-631

[2] RETRACTED: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition (Retracted Article) [J].

Amara, Khaled ;

Steen, Johanna ;

Murray, Fiona ;

Morbach, Henner ;

Fernandez-Rodriguez, Blanca M. ;

Joshua, Vijay ;

Engstrom, Marianne ;

Snir, Omri ;

Israelsson, Lena ;

Catrina, Anca I. ;

Wardemann, Hedda ;

Corti, Davide ;

Meffre, Eric ;

Klareskog, Lars ;

Malmstrom, Vivianne .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (03) :445-455

[3] Autocitrullination of Human Peptidyl Arginine Deiminase Type 4 Regulates Protein Citrullination During Cell Activation [J].

Andrade, Felipe ;

Darrah, Erika ;

Gucek, Marjan ;

Cole, Robert N. ;

Rosen, Antony ;

Zhu, Xiaoming .

ARTHRITIS AND RHEUMATISM, 2010, 62 (06) :1630-1640

[4] ALTERED REACTIVITY IN MIXED LYMPHOCYTE CULTURE OF LYMPHOCYTES FROM PATIENTS WITH RHEUMATOID ARTHRITIS [J].

ASTORGA, GP ;

WILLIAMS, RC .

ARTHRITIS AND RHEUMATISM, 1969, 12 (06) :547-&

[5] The Protective Role of HLA-DRB1*13 in Autoimmune Diseases [J].

Bettencourt, Andreia ;

Carvalho, Claudia ;

Leal, Barbara ;

Bras, Sandra ;

Lopes, Dina ;

da Silva, Ana Martins ;

Santos, Ernestina ;

Torres, Tiago ;

Almeida, Isabel ;

Farinha, Fatima ;

Barbosa, Paulo ;

Marinho, Antonio ;

Selores, Manuela ;

Correia, Joao ;

Vasconcelos, Carlos ;

Costa, Paulo P. ;

da Silva, Berta Martins .

JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015

[6] A "case control" study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis - Identification of types and subtypes using molecular biology (PCR.SSO) [J].

Bonfil, JJ ;

Dillier, FL ;

Mercier, P ;

Reviron, D ;

Foti, B ;

Sambuc, R ;

Brodeur, JM ;

Sedarat, C .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1999, 26 (02) :77-84

[7]

BRIGHTON SW, 1988, J RHEUMATOL, V15, P405

[8] Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis [J].

Burkhardt, H ;

Sehnert, B ;

Bockermann, R ;

Engström, Å ;

Kalden, JR ;

Holmdahl, R .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1643-1652

[9]

Carty SM, 2004, ANN RHEUM DIS, V63, P46

[10] Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis [J].

Cruz-Tapias, Paola ;

Perez-Fernandez, Oscar M. ;

Rojas-Villarraga, Adriana ;

Rodriguez-Rodriguez, Alberto ;

Arango, Maria-Teresa ;

Anaya, Juan-Manuel .

AUTOIMMUNE DISEASES, 2012, 2012

← 1 2 3 4 5 6 7 8 9 10 →