Ultra-low-level laser therapy

被引:37
作者
Baratto, Luigi [2 ]
Calza, Laura [1 ,3 ]
Capra, Roberto [2 ]
Gallamini, Michele [4 ]
Giardino, Luciana [3 ]
Giuliani, Alessandro [3 ]
Lorenzini, Luca [3 ]
Traverso, Silvano [4 ]
机构
[1] Univ Bologna, BioPharmaNet DIMORFIPA, I-40064 Ozzano Dell Emilia, Bologna, Italy
[2] La Colletta Bioengn Ctr, Arenzano, GE, Italy
[3] IRET Fdn, Ozzano Dell Emilia, BO, Italy
[4] RGMD SpA, Genoa, Italy
关键词
Low level laser theraphy; Pain; Acupoints; Mechanotransduction; NITRIC-OXIDE; ACTIN CYTOSKELETON; NERVE-STIMULATION; HIGH-FREQUENCY; SPINAL-CORD; HUMAN SKIN; RESPONSES; TISSUE; CELLS; ELECTROACUPUNCTURE;
D O I
10.1007/s10103-010-0837-2
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A growing number of laboratory and clinical studies over the past 10 years have shown that low-level laser stimulation (633 or 670 nm) at extremely low power densities (about 0.15 mW/cm(2)), when administered through a particular emission mode, is capable of eliciting significant biological effects. Studies on cell cultures and animal models as well as clinical trials give support to a novel therapeutic modality, which may be referred to as ultra low level laser therapy (ULLLT). In cultured neural cells, pulsed irradiation (670 nm, 0.45 mJ/cm(2)) has shown to stimulate NGF-induced neurite elongation and to protect cells against oxidative stress. In rats, anti-edema and anti-hyperalgesia effects following ULLL irradiation were found. Clinical studies have reported beneficial effects (also revealed through sonography) in the treatment of musculoskeletal disorders. The present paper reviews the existing experimental evidence available on ULLLT. Furthermore, the puzzling issue of the biophysical mechanisms that lie at the basis of the method is explored and some hypotheses are proposed. Besides presenting the state-of-the-art about this novel photobiostimulation therapy, the present paper aims to open up an interdisciplinary discussion and stimulate new research on this subject.
引用
收藏
页码:103 / 112
页数:10
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