The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer

被引：21

作者：

Chen, Yan-Zhen ^{[1
,2
]}

Yuan, Meng-Yun ^{[1
,2
]}

Chen, Ya Ling ^{[2
]}

Zhang, Xingxing ^{[1
]}

Xu, Xin-Tian ^{[2
]}

Liu, Shen-Lin ^{[1
]}

Zou, Xi ^{[1
]}

Tao, Jia-Lei ^{[1
]}

Qiang, Yong-Hu ^{[2
]}

Wu, Jian ^{[1
]}

Sun, Qing-Min ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China

来源：

CURRENT DRUG TARGETS | 2021年 / 22卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Traditional Chinese Medicine; gut microbiota; cancer; metabolites; immunity; inflammation; COLORECTAL-CANCER; PROFILE;

D O I：

10.2174/1389450122666210412141304

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gut microbiota is a complex microecosystem, which is called the second genome of the human body. Herbal medicine can balance tumor-suppressing bacteria and tumor-promoting bacteria and exert its anti-cancer effect by regulating gut microbiota. Traditional Chinese medicine (TCM) has a history of thousands of years in prevention and treatment of diseases in China. In recent decades, TCM has been shown to have an obvious advantage in prolonging the survival time and improving the living quality of patients with cancer. Notably, gut microbiota has become a new pathway to understanding TCM. In this review, we will focus on gut microbiota and tumor progression, especially the diversity, functionality and metabolites of gut microbiota affected by TCM in various cancer. We will also discuss the potential mechanism of gut microbiota for exploring TCM in anti-cancer effect. This article aims to comprehensively review the anti-cancer research of TCM by regulating gut microbiota, and address future perspectives and challenges of gut microbiota in TCM intervention for cancer.

引用

页码：1222 / 1231

页数：10

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