Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery

被引：376

作者：

Weeber, Fleur ^{[1
]}

Ooft, Salo N. ^{[1
]}

Dijkstra, Krijn K. ^{[1
]}

Voest, Emile E. ^{[1
,2
,3
,4
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Oncol & Immunol, NL-1066 CX Amsterdam, Noord Holland, Netherlands

[2] Netherlands Canc Inst, Dept Med Oncol, NL-1066 CX Amsterdam, Noord Holland, Netherlands

[3] Fdn Hubrecht Organoid Technol HUB, NL-3584CM Utrecht, Netherlands

[4] Canc Genom Nl, NL-3584 CG Utrecht, Netherlands

来源：

CELL CHEMICAL BIOLOGY | 2017年 / 24卷 / 09期

关键词：

PATIENT-DERIVED XENOGRAFTS; HUMAN INTESTINAL ORGANOIDS; DUCTAL PANCREATIC-CANCER; COMPARING SOLID TUMORS; STEM-CELLS; CYSTIC-FIBROSIS; COLORECTAL-CANCER; IN-VITRO; PRECISION MEDICINE; EPITHELIAL ORGANOIDS;

D O I：

10.1016/j.chembiol.2017.06.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor organoids are 3D cultures of cancer cells that can be derived on an individual patient basis with a high success rate. This creates opportunities to build large biobanks with relevant patient material that can be used to perform drug screens and facilitate drug development. The high take rate will also allow side-by-side comparison to evaluate the translational potential of this model system to the patient. These tumors-in-a-dish can be established for a variety of tumor types including colorectal, pancreas, stomach, prostate, and breast cancers. In this review, we highlight what is currently known about tumor organoid culture, the advantages and challenges of the model system, compare it with other pre-clinical cancer models, and evaluate its value for drug development.

引用

页码：1092 / 1100

页数：9

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