Epstein-Barr virus is absent in gastric superficial neoplastic lesions

被引：9

作者：

Ribeiro, Joana ^{[1
,2
]}

Malta, Mariana ^{[1
,3
]}

Galaghar, Ana ^{[4
]}

Afonso, Luis Pedro ^{[4
]}

Libanio, Diogo ^{[5
,6
]}

Medeiros, Rui ^{[1
,3
,7
]}

Dinis-Ribeiro, Mario ^{[5
,6
]}

Pimentel-Nunes, Pedro ^{[5
,6
]}

Sousa, Hugo ^{[1
,2
,7
,8
,9
]}

机构：

[1] Portuguese Oncol Inst Porto, Mol Oncol & Viral Pathol Grp CI IPOP, Rua Dr Antonio Bernardino de Almeida, P-4200072 Porto, Portugal

[2] Univ Porto, Fac Med, FMUP, Rua Al Prof Hernani Monteiro, P-4200072 Porto, Portugal

[3] Portuguese League Canc, Res Dept, Liga Portuguesa Canc Nucleo Reg Norte, Estr Interior Circunvalacao 6657, P-4200172 Porto, Portugal

[4] Portuguese Oncol Inst Porto, Dept Pathol, Rua Dr Antonio Bernardino de Almeida, P-4200072 Porto, Portugal

[5] Portuguese Oncol Inst Porto, Dept Gastroenterol, Rua Dr Antonio Bernardino de Almeida, P-4200072 Porto, Portugal

[6] Univ Porto, CINTESIS Ctr Hlth Technol & Serv Res, Ctr Invest Med, Fac Med, Porto, Portugal

[7] Portuguese Oncol Inst Porto, Virol Serv, Rua Dr Antonio Bernardino de Almeida, P-4200072 Porto, Portugal

[8] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, Campus Gualtar, P-4710057 Braga, Portugal

[9] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

来源：

VIRCHOWS ARCHIV | 2019年 / 475卷 / 06期

关键词：

Gastric dysplasia; Neoplastic lesion; Gastric cancer; Epstein-Barr virus (EBV); EBVaGC; HELICOBACTER-PYLORI; CANCER; INFECTION; CARCINOMA; CELLS; EBV; EXPRESSION; STOMACH; EVENT;

D O I：

10.1007/s00428-019-02670-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Epstein-Barr virus (EBV) has been associated with about 9% of all gastric carcinomas, but its role in gastric carcinogenesis remains unclear since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa. This study intends to determine the prevalence of EBV in gastric dysplasia and superficial neoplasia to clarify whether EBV infection is an early or late event in gastric cancer development. This retrospective study included a total of 242 gastric lesions from 199 consecutive patients who were referred for endoscopic resection. The histological classification of lesions includes 137 low- and high-grade dysplasia and 105 superficial carcinomas. EBV infection was investigated by EBER-ISH. Results showed that EBV was not detected in any epithelial cells of any case with dysplasia or superficial carcinomas, although we observed the presence of a small number of EBV-infected lymphocytes in 2.1% of all lesions. These results showed that EBV is not present in gastric dysplasia neither in superficial carcinomas suggesting that EBV carcinogenesis is a late event in well/moderately differentiated gastric carcinogenesis.

引用

页码：757 / 762

页数：6

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