Adult haematopoietic stem cell niches

被引：528
作者：
Crane, Genevieve M. [1 ,2 ]
Jeffery, Elise [1 ]
Morrison, Sean J. [1 ,3 ,4 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Childrens Res Inst, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
[3] Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
[4] Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 09期
基金：
美国国家卫生研究院;
关键词：
BONE-MARROW NICHE; EARLY MESENCHYMAL PROGENITORS; C-MPL LIGAND; STROMAL CELLS; SELF-RENEWAL; IN-VIVO; EXTRAMEDULLARY HEMATOPOIESIS; GROWTH-FACTOR; DEFINITIVE HEMATOPOIESIS; STEM/PROGENITOR CELLS;
D O I：
10.1038/nri.2017.53
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.
引用
收藏
页码：573 / 590
页数：18
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