Application of p-TSA in the one pot synthesis of N-methyl-3-nitro-aryl-benzo[4,5]imidazo[1,2-c]pyrimidin-2-amine

被引：24

作者：

Jadhav, Amol Maruti ^{[1
]}

Kim, Yeong Il ^{[2
]}

Lim, Kwon Taek ^{[1
]}

Jeong, Yeon Tae ^{[1
]}

机构：

[1] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea

[2] Pukyong Natl Univ, Dept Chem, Busan 608737, South Korea

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 06期

关键词：

N-Methyl-3-nitro-aryl-benzo[4,5]imidazo [1,2-alpyrimidin-2-amine; Michael reaction; One-pot synthesis; Multi-component reaction; SOLVENT-FREE CONDITIONS; PYRIMIDINE-DERIVATIVES; STRUCTURAL ANALOGS; GREEN SYNTHESIS; EFFICIENT; CATALYST; INHIBITORS; ALPHA; WATER;

D O I：

10.1016/j.tetlet.2018.01.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, eco-friendly, and cost-effective method has been developed for the synthesis of Nmethy1-3-nitro-aryl-benzo[4,51imidazo[1,2-a]pyrimidin-2-amine derivatives using 2-aminobenzimida-zole, aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine, in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in ethanol at 80 degrees C conditions. The advantages of this method are the use of an inexpensive and readily available catalyst, shorter reaction times, a wide range of functional group tolerance, and high yield of products via a simple experimental and work-up procedure. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：554 / 557

页数：4

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