Metal-free one-pot α-benzoxylation of benzylic alcohols with acids or aldehydes

被引：7
|
作者：
Zhu, Yefu
Zheng, Yong
Song, Weibin
Wei, Bole
Xuan, Lijiang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 04期
关键词：
nBu(4)NI; TBHP; alpha-Benzoxy ketones; Cross-dehydrogenative coupling; DEHYDROGENATIVE COUPLING CDC; TERT-BUTYL HYDROPEROXIDE; C-H BONDS; CARBOXYLIC-ACIDS; CARBONYL-COMPOUNDS; TRANSITION-METAL; EFFICIENT SYNTHESIS; ACETOXY KETONES; OXIDATION; ACYLATION;
D O I：
10.1016/j.tetlet.2017.12.030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free strategy has been developed for alpha-benzoxylation of benzylic alcohols with acids or aldehydes. The reaction proceeds via sequential oxidation and alpha-benzoxylation in one pot. Importantly, the reactions are performed in metal-free condition and utilize cheap aqueous TBHP as an oxidant, affording alpha-benzoxy ketones in moderate to good yields. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：368 / 371
页数：4
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