Cannabinoid Markers in Biological Fluids and Tissues: Revealing Intake

被引：41
作者：
Huestis, Marilyn A. [1 ,2 ]
Smith, Michael L. [2 ]
机构：
[1] Thomas Jefferson Univ, Inst Emerging Hlth Profess, Philadelphia, PA 19107 USA
[2] Huestis & Smith Toxicol LLC, Severna Pk, MD 21146 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 02期
基金：
美国国家卫生研究院;
关键词：
SYNTHETIC CANNABINOIDS; ORAL FLUID; WHOLE-BLOOD; HUMAN URINE; TEMPORAL INDICATION; THC-GLUCURONIDE; MARIJUANA USE; LC-MS/MS; PLASMA; DELTA(9)-TETRAHYDROCANNABINOL;
D O I：
10.1016/j.molmed.2017.12.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding cannabis and synthetic cannabinoid intake history is vital for treating drug dependence, investigating cannabinoid effects, and providing information to healthcare personnel, medical examiners, and public health officials; this is particularly relevant today with cannabis medicalization and legalization. Required information includes identifying exposure, time of use, frequency of use, relapse, withdrawal, and predicting cannabinoid effects. Recent controlled cannabinoid administration studies enable the development of models and markers to better identify patterns of intake and exposure. Future challenges include developing behavioral markers of cannabis impairment, bringing to market breathalyzers for cannabinoid detection, and identifying markers of recent cannabis intake in diverse biological matrices. We posit that biological monitoring of cannabinoids and metabolites will improve the characterization of cannabis and synthetic cannabinoid intake history.
引用
收藏
页码：156 / 172
页数：17
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