New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd

被引：17

作者：

Shi, Pingping ^{[1
]}

Chao, Liping ^{[1
]}

Wang, Tingtxing ^{[2
]}

Liu, Erwei ^{[1
,2
]}

Han, Lifeng ^{[1
,2
]}

Zong, Qi ^{[1
]}

Li, Xiaoxia ^{[1
]}

Zhang, Yi ^{[1
]}

Wang, Tao ^{[1
,2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China

来源：

FITOTERAPIA | 2015年 / 103卷

关键词：

Lepidium apetalum; Flavonoid glycosides; HepG2; cells; Triglyceride accumulation inhibitory effects;

D O I：

10.1016/j.fitote.2015.04.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten flavonoid glycosides, apetalumosides A (1), B-1-B-7 (2-8), and C (9), quercetin 3-O-(2,6-di-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Wind. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1-9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1-3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：197 / 205

页数：9

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