Hypotony in Patients with Uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

被引：37

作者：

Sen, H. Nida ^{[1
]}

Drye, Lea T. ^{[2
]}

Goldstein, Debra A. ^{[3
]}

Larson, Theresa A. ^{[1
]}

Merrill, Pauline T. ^{[4
]}

Pavan, Peter R. ^{[5
]}

Sheppard, John D. ^{[6
,7
]}

Burke, Alyce ^{[2
]}

Srivastava, Sunil K. ^{[8
]}

Jabs, Douglas A. ^{[2
,9
,10
]}

机构：

[1] NEI, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USA

[4] Rush Univ, Med Ctr, Dept Ophthalmol, Chicago, IL 60612 USA

[5] Univ S Florida, Coll Med, Dept Ophthalmol, Tampa, FL USA

[6] Virginia Eye Consultants, Dept Ophthalmol, Norfolk, VA USA

[7] Thomas R Lee Ctr Ocular Pharmacol, Norfolk, VA USA

[8] Emory Univ, Ctr Eye, Dept Ophthalmol, Atlanta, GA 30322 USA

[9] Mt Sinai Sch Med, Dept Ophthalmol, New York, NY USA

[10] Mt Sinai Sch Med, Dept Med, New York, NY USA

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2012年 / 20卷 / 02期

关键词：

hypotony; multicenter uveitis steroid treatment trial; uveitis; visual impairment; visual loss; ARTHRITIS-ASSOCIATED UVEITIS; CHRONIC OCULAR HYPOTONY; VISUAL-ACUITY; SURGERY; COMPLICATIONS; SARCOIDOSIS; MANAGEMENT; DISEASE; INFLAMMATION; CHILDHOOD;

D O I：

10.3109/09273948.2011.647228

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To assess the prevalence of hypotony in patients with severe forms of uveitis. Methods: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified. Results: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis >= 5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. < 51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01). Conclusions: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

引用

页码：104 / 112

页数：9

共 30 条

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