Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus

Aims: Recently, it was suggested that betatrophin has a role in controlling pancreatic beta cell proliferation and lipid metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and MDA along with other biochemical indicators in type 2 diabetes mellitus (T2DM) in a sample of the Iraqi population was examined in the present investigation. Methods: A total of 31 patients diagnosed with T2DM and 30 adult subjects without diabetes were matched in age and gender in a case-control study. Logistic and linear regression models were performed to examine the role of MDA and betatrophin in T2DM and triglyceride, respectively. Results: The study confirmed a higher concentration of LDL (124.45 vs. 102.70 mg/dL; P = .001) and TG (191.13 vs. 103.83 mg/dL; P <.0001), insulin (18.40 vs. 10.97 mU/mL; P <.0001), and Hs. CRP (5.39 vs. 2.80 mg/L; P = .033) in diabetic patients compared to the controls. No significant difference in betatrophin and MDA was found between diabetic patients and non-diabetic healthy subjects. The study showed triglyceride as the only predictor of T2DM (P = .028). Similarly, total cholesterol (P <.0001), HDL (P = .001), LDL (P <.0003), and MDA (P = .010) were shown as predictors of triglyceride in diabetic patients. Conclusion: The present study that triglyceride is a direct and MDA is an indirect predictor for T2DM. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.