Can Youthful Mesenchymal Stem Cells from Wharton's Jelly Bring a Breath of Fresh Air for COPD?

被引：7

作者：

Janczewski, Andrzej M. ^{[1
]}

Wojtkiewicz, Joanna ^{[2
,3
,4
]}

Malinowska, Ewa ^{[1
]}

Doboszynska, Anna ^{[1
]}

机构：

[1] Univ Warmia & Mazury, Fac Heath Sci, Dept Pulmonol, Jagiellonska 78, PL-10357 Olsztyn, Poland

[2] Univ Warmia & Mazury, Dept Pathophysiol, Fac Med, Warszawska 30, PL-10082 Olsztyn, Poland

[3] Univ Warmia & Mazury, Lab Regenerat Med, Fac Med, Warszawska 30, PL-10082 Olsztyn, Poland

[4] Fdn Nerve Cells Regenerat, Warszawska 30, PL-10082 Olsztyn, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期

关键词：

chronic obstructive pulmonary disease; Wharton's jelly; mesenchymal stem cells; anti-inflammatory effects; immunomodulation; therapeutic applications; ELASTASE-INDUCED EMPHYSEMA; OBSTRUCTIVE PULMONARY-DISEASE; BONE-MARROW-CELLS; STROMAL CELLS; UMBILICAL-CORD; IMMUNOLOGICAL FEATURES; OXIDATIVE STRESS; LUNG EPITHELIUM; GROWTH-FACTOR; MECHANISMS;

D O I：

10.3390/ijms18112449

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality, projected to become the 3rd cause of disease mortality worldwide by 2020. COPD is characterized by persistent and not fully reversible airflow limitation that is usually progressive and is associated with an abnormal chronic inflammatory response of the lung to noxious agents including cigarette smoke. Currently available therapeutic strategies aim to ease COPD symptoms but cannot prevent its progress or regenerate physiological lung structure or function. The urgently needed new approaches for the treatment of COPD include stem cell therapies among which transplantation of mesenchymal stem cells derived from Wharton's jelly (WJ-MSCs) emerges as a promising therapeutic strategy because of the unique properties of these cells. The present review discusses the main biological properties of WJ-MSCs pertinent to their potential application for the treatment of COPD in the context of COPD pathomechanisms with emphasis on chronic immune inflammatory processes that play key roles in the development and progression of COPD.

引用

页数：18

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