Synthesis, characterization, DNA interaction and antibacterial activities of two tetranuclear cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

被引：36

作者：

Xu, Zhi-hong ^{[1
]}

Zhang, Xiao-wei ^{[1
]}

Zhang, Wan-qiang ^{[1
]}

Gao, Yuan-hao ^{[1
]}

Zeng, Zheng-zhi ^{[2
]}

机构：

[1] Xuchang Univ, Coll Chem & Chem Engn, Xuchang 461000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2011年 / 14卷 / 10期

关键词：

Salicylaldehyde; 2-phenylquinoline-4-carboylhydrazone; Tetranuclear complex; Groove binding; Antibacterial activity; TRANSITION-METAL-COMPLEXES; BINDING PROPERTIES; CRYSTAL-STRUCTURE; ZN COMPLEXES; COPPER; NI;

D O I：

10.1016/j.inoche.2011.06.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H2L), and its novel tetranuclear cobalt(II), nickel(II) complexes have been synthesized and characterized. The crystal structure of (NiL)(2)center dot[NiL(H2O)(DMF)](2)center dot H2O. DMF obtained from DMF solutions of compound 2 was determined by X-ray diffraction analysis. The DNA-binding investigation suggests that the two complexes bind to DNA via groove binding mode. The in vitro antibacterial activity of complexes against Escherichia coli. Staphylococcus aureus, Bacillus subtilis was screened and compared to the activity of the free ligand, the antibacterial activity of complex 1 is active than complex 2 which is in consistent with their DNA-binding behaviors. (C)2011 Elsevier B.V. All rights reserved.

引用

页码：1569 / 1573

页数：5

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