Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

被引：7
作者：
Xian, Peng-Jie [1 ]
Liu, Shu-Zhi [2 ]
Wang, Wen-Jing [2 ]
Yang, Sheng-Xiang [3 ,4 ]
Feng, Zhang [1 ]
Yang, Xiao-Long [1 ,2 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China
[2] South Cent Minzu Univ, Modernizat Engn Technol Res Ctr Ethn Minor Med Hub, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
[3] Zhejiang A&F Univ, Zhejiang Prov Collaborat Innovat Ctr Bamboo Resour, Linan 311300, Peoples R China
[4] Zhejiang A&F Univ, Zhejiang Prov Key Lab Chem Utilizat Forestry Bioma, Linan 311300, Peoples R China
来源：
PHYTOCHEMISTRY | 2022年 / 202卷
基金：
中国国家自然科学基金;
关键词：
Emericella sp; Trichocomaceae; Panax notoginseng; Araliaceae; OSMAC strategy; Antibacterial activity; Antifungal activity; DERIVATIVES; DISCOVERY; PRENYLXANTHONES; ANTIFUNGAL;
D O I：
10.1016/j.phytochem.2022.113303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 mu g/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 mu g/mL and 3.13 mu g/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 mu g/mL.
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页数：11
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