Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

被引：7

作者：

Xian, Peng-Jie ^{[1
]}

Liu, Shu-Zhi ^{[2
]}

Wang, Wen-Jing ^{[2
]}

Yang, Sheng-Xiang ^{[3
,4
]}

Feng, Zhang ^{[1
]}

Yang, Xiao-Long ^{[1
,2
]}

机构：

[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China

[2] South Cent Minzu Univ, Modernizat Engn Technol Res Ctr Ethn Minor Med Hub, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China

[3] Zhejiang A&F Univ, Zhejiang Prov Collaborat Innovat Ctr Bamboo Resour, Linan 311300, Peoples R China

[4] Zhejiang A&F Univ, Zhejiang Prov Key Lab Chem Utilizat Forestry Bioma, Linan 311300, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 202卷

基金：

中国国家自然科学基金;

关键词：

Emericella sp; Trichocomaceae; Panax notoginseng; Araliaceae; OSMAC strategy; Antibacterial activity; Antifungal activity; DERIVATIVES; DISCOVERY; PRENYLXANTHONES; ANTIFUNGAL;

D O I：

10.1016/j.phytochem.2022.113303

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 mu g/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 mu g/mL and 3.13 mu g/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 mu g/mL.

引用

页数：11

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