Antiphospholipid Antibodies and Lipids in Hematological Malignancies

被引：11

作者：

Barreno-Rocha, Sonia Guadalupe ^{[1
,2
]}

Guzman-Silahua, Sandra ^{[1
,2
]}

Rodriguez-Davila, Sinai-del-Carmen ^{[1
]}

Gavilanez-Chavez, Guadalupe Estela ^{[1
,2
]}

Cardona-Munoz, Ernesto German ^{[2
]}

Riebeling-Navarro, Carlos ^{[3
]}

Rubio-Jurado, Benjamin ^{[1
,4
]}

Nava-Zavala, Arnulfo Hernan ^{[1
,5
,6
]}

机构：

[1] CMNO OOAD Jalisco Inst Mexicano Seguro Social, Unidad Invest Epidemiol & Serv Salud, Guadalajara 44340, Mexico

[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Programa Doctorado Farmacol, Guadalajara 44340, Mexico

[3] UMAE HP CMN SXXI, Unidad Invest Epidemiol Clin, Mexico City 06720, DF, Mexico

[4] UMAE, Hosp Especialidades, Ctr Med Nacl Occidente,Div Oncohematol, Dept Clin Hematol,Inst Mexicano Seguro Social, Guadalajara 44340, Mexico

[5] Univ Autonoma Guadalajara, Programa Int Med, Guadalajara 44670, Mexico

[6] Hosp Gen Occidente Seguro Social, Secretaria Salud Jalisco, Dept Inmunol & Reumatol, Guadalajara 45070, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 08期

关键词：

anti-beta 2 glycoprotein I; anticardiolipin; antiphospholipid antibodies; hematological malignancies; lipid; lupus anticoagulant; FATTY-ACID SYNTHASE; ANTINUCLEAR ANTIBODIES; CLINICAL-SIGNIFICANCE; CELL LYMPHOMA; CANCER; PREVALENCE; METABOLISM; PHOSPHATIDYLCHOLINE; PHOSPHOLIPIDS; ACTIVATION;

D O I：

10.3390/ijms23084151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the main groups of lipids is phospholipids, which are mainly involved in forming cell membranes. Neoplastic processes such as cell replication have increased lipid synthesis, making tumor cells dependent on this synthesis to maintain their requirements. Antiphospholipid antibodies attack phospholipids in the cell membranes. Three main types of antiphospholipid antibodies are recognized: anti-beta 2 glycoprotein I (anti-beta 2GP-I), anticardiolipin (aCL), and lupus anticoagulant (LA). These types of antibodies have been proven to be present in hematological neoplasms, particularly in LH and NHL. This review on antiphospholipid antibodies in hematological neoplasms describes their clinical relationship as future implications at the prognostic level for survival and even treatment.

引用

页数：12

共 75 条

[21] Interacting Cancer Machineries: Cell Signaling, Lipid Metabolism, and Epigenetics [J].