Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery

被引：57

作者：

Shen, Shou-Cang ^{[1
]}

Ng, Wai Kiong ^{[1
]}

Shi, Zhilong ^{[2
]}

Chia, Leonard ^{[1
]}

Neoh, Koon Gee ^{[2
]}

Tan, Reginald Beng Hee ^{[1
,2
]}

机构：

[1] ASTAR, Inst Chem & Engn Sci, Singapore 627833, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 10期

关键词：

IN-VITRO RELEASE; MECHANICAL-PROPERTIES; GENTAMICIN RELEASE; EMERGING STANDARD; PROPHYLACTIC USE; DRUG-DELIVERY; INFECTION; ELUTION; BEADS; PMMA;

D O I：

10.1007/s10856-011-4397-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(methyl methacrylate)-based bone cements are functionalized with mesoporous silica nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to reduce the risk of post-operative joint infection. To overcome the limited drug release of 5% for only 1 day with the current commercial-grade bone cements, a 8 wt% MSN-formulated bone cement is able to increase the drug release efficiency by 14-fold and sustain the release for up to 80 days. The loaded MSN is suggested to build up an effective network of rod-shaped silica particles with uniformly arranged nanoporous channels, which is responsible for the effective drug diffusion and extend time-release to the external surfaces. MSN has no detrimental effect on the critical weight-bearing bending modulus and compression strength of bone cement. In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSN-formulated bone cement.

引用

页码：2283 / 2292

页数：10

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