PEG-induced orientation enhancement of supported lipid multi-bilayers revealed by surface X-ray diffraction

被引：4

作者：

Xu, Yihui ^{[1
]}

Xie, Qing ^{[2
]}

Fan, Jiadong ^{[1
]}

Gu, Yueliang ^{[2
]}

Li, Xiaolong ^{[2
]}

Liu, Zhi ^{[1
]}

Jiang, Huaidong ^{[1
]}

机构：

[1] ShanghaiTech Univ, Ctr Transformat Sci, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China

[2] Chinese Acad Sci, Shanghai Adv Res Inst, 99 Haike Rd, Shanghai 201210, Peoples R China

来源：

SURFACES AND INTERFACES | 2022年 / 29卷

基金：

中国国家自然科学基金;

关键词：

PEG; Lipid multi-bilayer; X-ray diffraction; Membrane orientation; Enhancement; POLYETHYLENE-GLYCOL; POLY(ETHYLENE GLYCOL); DEPLETION ATTRACTION; MEMBRANE-FUSION; PART; NANOPARTICLES; FLUCTUATIONS; SCATTERING; STABILITY; NEUTRON;

D O I：

10.1016/j.surfin.2022.101762

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polyethylene glycol (PEG) is one of the most widely used polymers in cosmetic and biomedical products. The supported lipid multi-bilayer (SLMB) is an important model membrane, which is highly advantageous to surface diffraction techniques. In this study, in-situ grazing-incidence X-ray diffraction, X-ray reflectivity, and X-ray rocking scans are combined to systematically study the effects of PEG on SLMBs. A structure restoring effect of PEG is revealed, which is indicated by the reduced bilayer periodicity, improved molecular packing, and enhanced membrane orientation of the SLMBs. Moreover, this effect is found to be irreversible; i.e., removing PEG does not eliminate this effect. This finding may contribute to a better understanding of PEG-membrane interaction and the further biomedical applications of PEG.

引用

页数：7

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