Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

被引:35
作者
Ito, E
Suzuki-Toyota, F
Toshimori, K
Fuwa, H
Tachibana, K
Satake, M
Sasaki, M
机构
[1] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chuo Ku, Chiba 2608673, Japan
[2] Chiba Univ, Grad Sch Med, Dept Anat & Dev Biol, Chuo Ku, Chiba 2608670, Japan
[3] Univ Tokyo, Grad Sch Sci, Dept Chem, Tokyo 1130033, Japan
[4] CREST, JST, Bunkyo Ku, Tokyo 1130033, Japan
[5] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan
关键词
gambierol; pathological effect; mouse; alveolar macrophage;
D O I
10.1016/j.toxicon.2003.09.011
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 mug/kg by i.p. and i.v., and 150 mug/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:733 / 740
页数:8
相关论文
共 20 条
[1]   Total synthesis of (-)-gambierol [J].
Fuwa, H ;
Kainuma, N ;
Tachibana, K ;
Sasaki, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (50) :14983-14992
[2]   Total synthesis of gambierol [J].
Fuwa, H ;
Sasaki, M ;
Satake, M ;
Tachibana, K .
ORGANIC LETTERS, 2002, 4 (17) :2981-2984
[3]   Morphological observations of diarrhea in mice caused by experimental ciguatoxicosis [J].
Ito, E ;
Yasumoto, T ;
Terao, K .
TOXICON, 1996, 34 (01) :111-122
[4]   First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method [J].
Ito, E ;
Kondo, F ;
Harada, K .
TOXICON, 2000, 38 (01) :37-48
[5]   Intestinal injuries caused by experimental palytoxicosis in mice [J].
Ito, E ;
Ohkusu, M ;
Yasumoto, T .
TOXICON, 1996, 34 (06) :643-652
[6]   Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland [J].
Ito, E ;
Satake, M ;
Ofuji, K ;
Kurita, N ;
McMahon, T ;
James, K ;
Yasumoto, T .
TOXICON, 2000, 38 (07) :917-930
[7]   Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning [J].
Ito, E ;
Nagai, H .
TOXICON, 2000, 38 (01) :123-132
[8]   Pathological effects of lyngbyatoxin A upon mice [J].
Ito, E ;
Satake, M ;
Yasumoto, T .
TOXICON, 2002, 40 (05) :551-556
[9]   The absolute configuration of gambierol, a toxic marine polyether from the dinoflagellate, Gambierdiscus toxicus [J].
Morohashi, A ;
Satake, M ;
Yasumoto, T .
TETRAHEDRON LETTERS, 1999, 40 (01) :97-100
[10]   STRUCTURE AND PARTIAL STEREOCHEMICAL ASSIGNMENTS FOR MAITOTOXIN, THE MOST TOXIC AND LARGEST NATURAL NON-BIOPOLYMER [J].
MURATA, M ;
NAOKI, H ;
MATSUNAGA, S ;
SATAKE, M ;
YASUMOTO, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (16) :7098-7107