Serotonin syndrome and rhabdomyolysis in venlafaxine poisoning: a case report

被引：0

作者：

Hanekamp, BB ^{[1
]}

Zijlstra, JG ^{[1
]}

Tulleken, JE ^{[1
]}

Ligtenberg, JJM ^{[1
]}

van der Werf, TS ^{[1
]}

Hofstra, LS ^{[1
]}

机构：

[1] Univ Groningen, Med Ctr, NL-9700 RB Groningen, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2005年 / 63卷 / 08期

关键词：

rhabdomyolysis; self-poisoning; serotonin syndrome; venlafaxine;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Newer, more selective, antidepressant agents are increasingly being used as first-line treatment. However, clinical experience in patients after a deliberate overdose is limited. We present a case of venlafaxine intoxication complicated by a late rise in creatine kinase, seizures and serotonin syndrome. Rhabdomyolysis prolonged the hospital stay in our patient but had no other serious consequences. Physicians should be aware of this late phenomenon in patients with venlafaxine poisoning.

引用

页码：316 / 318

页数：3

共 12 条

[1] Cardiovascular and neurological toxicity of venlafaxine
Blythe, D
Hackett, LP
[J]. HUMAN & EXPERIMENTAL TOXICOLOGY, 1999, 18 (05) : 309 - 313
[2] The serotonin syndrome
Boyer, EW
Shannon, M
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (11) : 1112 - 1120
[3] Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data
Buckley, NA
McManus, PR
[J]. BRITISH MEDICAL JOURNAL, 2002, 325 (7376): : 1332 - 1333
[4] Venlafaxine: A 2003 update
Gutierrez, MA
Stimmel, GL
Aiso, JY
[J]. CLINICAL THERAPEUTICS, 2003, 25 (08) : 2138 - 2154
[5] Lines of evidence on the risks of suicide with selective serotonin reuptake inhibitors
Healy, D
[J]. PSYCHOTHERAPY AND PSYCHOSOMATICS, 2003, 72 (02) : 71 - 79
[6] Comparative toxicity of citalopram and the newer antidepressants after overdose
Kelly, CA
Dhaum, N
Laing, WJ
Strachan, FE
Good, AM
Bateman, DN
[J]. JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2004, 42 (01): : 67 - 71
[7] SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression
Kent, JM
[J]. LANCET, 2000, 355 (9207) : 911 - 918
[8] Pan JJ, 2003, ANN PHARMACOTHER, V37, P209
[9] The safety and tolerability of venlafaxine hydrochloride: Analysis of the clinical trials database
Rudolph, RL
Derivan, AT
[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1996, 16 (03) : S54 - S59
[10] STERNBACH H, 1991, AM J PSYCHIAT, V148, P705

← 1 2 →