Functional Connectivity Abnormalities of Brain Regions with Structural Deficits in Young Adult Male Smokers

被引：17

作者：

Bu, Limei ^{[1
]}

Yu, Dahua ^{[1
]}

Su, Shaoping ^{[1
]}

Ma, Yao ^{[1
]}

von Deneen, Karen M. ^{[2
,3
]}

Luo, Lin ^{[4
]}

Zhai, Jinquan ^{[4
]}

Liu, Bo ^{[4
]}

Cheng, Jiadong ^{[2
,3
]}

Guan, Yanyan ^{[2
,3
]}

Li, Yangding ^{[2
,3
]}

Bi, Yanzhi ^{[2
,3
]}

Xue, Ting ^{[1
]}

Lu, Xiaoqi ^{[1
]}

Yuan, Kai ^{[1
,2
,3
]}

机构：

[1] Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou, Peoples R China

[2] Xidian Univ, Sch Life Sci & Technol, Xian, Peoples R China

[3] Minist Educ, Engn Res Ctr Mol & NeuroImaging, Beijing, Peoples R China

[4] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Baotou Med Coll, Dept Med Imaging, Baotou, Peoples R China

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2016年 / 10卷

基金：

中国国家自然科学基金;

关键词：

smoking; voxel-based morphometry (VBM); resting state; functional connectivity; anterior cingulate cortex; putamen; ANTERIOR CINGULATE CORTEX; WHITE-MATTER DEVELOPMENT; SMOKING-CESSATION; DRUG-ADDICTION; INSULA; VOLUME; ADOLESCENCE; ABSTINENCE; FREQUENCY; SEVERITY;

D O I：

10.3389/fnhum.2016.00494

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Smoking is one of the most prevalent dependence disorders. Previous studies have detected structural and functional deficits in smokers. However, few studies focused on the changes of resting state functional connectivity (RSFC) of the brain regions with structural deficits in young adult smokers. Twenty-six young adult smokers and 26 well-matched healthy non-smokers participated in our study. Voxel-based morphometry (VBM) and RSFC were employed to investigate the structural and functional changes in young adult smokers. Compared with healthy non-smokers, young smokers showed increased gray matter (GM) volume in the left putamen and decreased GM volume in the left anterior cingulate cortex (ACC). Moreover, GM volume in the left ACC has a negative correlation trend with pack-years and GM volume in the left putamen was positively correlated with pack-years. The left ACC and putamen with abnormal volumes were chosen as the regions of interest (ROIs) for the RSFC analysis. We found that smokers showed increased RSFC between the left ACC and right amygdala and between the left putamen and right anterior insula. We revealed structural and functional deficits within the frontostriatal circuits in young smokers, which may shed new insights into the neural mechanisms of smoking.

引用

页数：8

共 61 条

[1] Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes [J].

Addicott, Merideth A. ;

Sweitzer, Maggie M. ;

Froeliger, Brett ;

Rose, Jed E. ;

McClernon, Francis J. .

NEUROPSYCHOPHARMACOLOGY, 2015, 40 (11) :2648-2656

[2] The anterior cingulate cortex - The evolution of an interface between emotion and cognition [J].

Allman, JM ;

Hakeem, A ;

Erwin, JM ;

Nimchinsky, E ;

Hof, P .

UNITY OF KNOWLEDGE: THE CONVERGENCE OF NATURAL AND HUMAN SCIENCE, 2001, 935 :107-117

[3] Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[4] White matter development during late adolescence in healthy males: A cross-sectional diffusion tensor imaging study [J].

Ashtari, Manzar ;

Cervellione, Kelly L. ;

Hasan, Khader M. ;

Wu, Jinghui ;

McIlree, Carolyn ;

Kester, Hana ;

Ardekani, Babak A. ;

Roofeh, David ;

Szeszko, Philip R. ;

Kumra, Sanjiv .

NEUROIMAGE, 2007, 35 (02) :501-510

[5] White matter development during childhood and adolescence: A cross-sectional diffusion tensor imaging study [J].

Barnea-Goraly, N ;

Menon, V ;

Eckert, M ;

Tamm, L ;

Bammer, R ;

Karchemskiy, A ;

Dant, CC ;

Reiss, AL .

CEREBRAL CORTEX, 2005, 15 (12) :1848-1854

[6]

Bi Y., 2016, BRAIN IMAGING BEHAV, DOI DOI 10.1007/S11682-016-9511-Z

[7] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].

BISWAL, B ;

YETKIN, FZ ;

HAUGHTON, VM ;

HYDE, JS .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541

[8] Brain metabolic changes during cigarette craving [J].

Brody, AL ;

Mandelkern, MA ;

London, ED ;

Childress, AR ;

Lee, GS ;

Bota, RG ;

Ho, ML ;

Saxena, S ;

Baxter, LR ;

Madsen, D ;

Jarvik, ME .

ARCHIVES OF GENERAL PSYCHIATRY, 2002, 59 (12) :1162-1172

[9] Neural substrates of resisting craving during cigarette cue exposure [J].

Brody, Arthur L. ;

Mandelkern, Mark A. ;

Olmstead, Richard E. ;

Jou, Jennifer ;

Tiongson, Emmanuelle ;

Allen, Valerie ;

Scheibal, David ;

London, Edythe D. ;

Monterosso, John R. ;

Tiffany, Stephen T. ;

Korb, Alex ;

Gan, Joanna J. ;

Cohen, Mark S. .

BIOLOGICAL PSYCHIATRY, 2007, 62 (06) :642-651

[10] Cognitive and emotional influences in anterior cingulate cortex [J].

Bush, G ;

Luu, P ;

Posner, MI .

TRENDS IN COGNITIVE SCIENCES, 2000, 4 (06) :215-222

← 1 2 3 4 5 6 7 →