Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition

被引：131

作者：

Vitale, Salvatore Giovanni ^{[1
]}

Capriglione, Stella ^{[2
]}

Zito, Gabriella ^{[3
]}

Lopez, Salvatore ^{[4
,5
]}

Gulino, Ferdinando Antonio ^{[6
]}

Di Guardo, Federica ^{[7
]}

Vitagliano, Amerigo ^{[8
]}

Noventa, Marco ^{[8
]}

La Rosa, Valentina Lucia ^{[9
]}

Sapia, Fabrizio ^{[10
]}

Valenti, Gaetano ^{[10
]}

Rapisarda, Agnese Maria Chiara ^{[10
]}

Peterlunger, Isabel ^{[11
]}

Rossetti, Diego ^{[12
]}

Lagana, Antonio Simone ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol Adulthood & Childhood G Barresi, Unit Gynecol & Obstet, Via Consolare Valeria 1, I-98125 Messina, Italy

[2] Ist Sicurezza Sociale, Dept Obstet & Gynecol, Cailungo Borgo Maggiore 47893, San Marino

[3] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Dept Obstet & Gynecol, Via Istria 65-1, I-34137 Trieste, Italy

[4] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, 333 Cedar St, New Haven, CT 06520 USA

[5] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy

[6] Umberto I Hosp, Dept Obstet & Gynaecol, Enna, Italy

[7] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via Tindaro 2, I-95124 Catania, Italy

[8] Univ Padua, Dept Woman & Child Hlth, Via Giustiniani 3, I-35128 Padua, Italy

[9] Univ Catania, Unit Psychodiagnost & Clin Psychol, Via Santa Sofia 78, I-95124 Catania, Italy

[10] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via Santa Sofia 78, I-95124 Catania, Italy

[11] Univ Trieste, Osped Cattinara, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy

[12] Desenzano del Garda Hosp, Sect Gavardo, Unit Gynecol & Obstet, Via A Gosa 74, I-25085 Brescia, Italy

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2019年 / 299卷 / 02期

关键词：

Gynaecological cancers; Elderly; Ovarian cancer; Cervical cancer; Endometrial cancer; PELVIC RADIATION-THERAPY; QUALITY-OF-LIFE; CYTOREDUCTIVE SURGERY; RADICAL HYSTERECTOMY; GREATER-THAN-OR-EQUAL-TO-70; YEARS; PERIOPERATIVE MORBIDITY; CONCURRENT CHEMOTHERAPY; FERTILITY PRESERVATION; GYNECOLOGICAL CANCER; SURGICAL-MANAGEMENT;

D O I：

10.1007/s00404-018-5006-z

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

PurposeGynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.MethodsWe searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms ovarian cancer, endometrial cancer, cervical cancer, gynecological cancers combined with elderly', cancer', clinical trial' and geriatric assessment'.ResultsThe search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: Endometrial cancer, Ovarian cancer and Cervical cancer.ConclusionsThe present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.

引用

页码：299 / 315

页数：17

共 90 条

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