Design of a near-infrared-triggered photo/thermal dual-responsive composite carrier with excellent biocompatibility for controllable drug release

被引：10

作者：

Tian, Mengyuan ^{[1
]}

Xin, Fuhua ^{[1
]}

Gao, Yanjing ^{[1
]}

Nie, Jun ^{[2
,3
]}

Sun, Fang ^{[1
,2
,4
]}

机构：

[1] Beijing Univ Chem Technol, Coll Chem, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China

[3] Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing, Peoples R China

[4] Beijing Univ Chem Technol, Anqing Res Inst, Anqing, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2022年 / 139卷 / 17期

基金：

中国国家自然科学基金;

关键词：

coumarin; drug release; dual-response; polydopamine; upconversion; NANOPARTICLES; ENCAPSULATION; DOPAMINE; NANOGELS; SIZE;

D O I：

10.1002/app.52029

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A near-infrared (NIR)-triggered photo/thermal dual-responsive composite carrier (UCNPs-NG-PDA) was designed and fabricated by the incorporation of upconversion nanoparticles (UCNPs), coumarin-based photo/thermal-responsive nanogel (NG) with uniform particle size (193 nm) and polydopamine (PDA) particles. UCNPs-NG-PDA has good photothermal conversion capability because of the introduction of PDA. The light and heat dual-responsiveness of coumarin-based nanogels markedly enhances the drug release of UCNPs-NG-PDA. Under NIR irradiation for only 20 min, the final cumulative release reaches 79.4% and is much higher than that (58.8%) under UV irradiation. More remarkably, the UCNPs-NG-PDA exhibits an excellent biocompatibility and has fascinating application prospects in drug delivery fields.

引用

页数：10