New developments in the biology of fibroblast growth factors

被引：94

作者：

Ornitz, David M. ^{[1
]}

Itoh, Nobuyuki ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63130 USA

[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto, Japan

来源：

WIRES MECHANISMS OF DISEASE | 2022年 / 14卷 / 04期

关键词：

fibroblast growth factors; organogenesis; receptor tyrosine kinase; regeneration; tyrosine kinase inhibitors; NONALCOHOLIC FATTY LIVER; GONADOTROPIN-RELEASING-HORMONE; RECEPTOR TYROSINE KINASES; MESENCHYMAL STEM-CELLS; INDUCED LUNG INJURY; X-LINKED HYPOPHOSPHATEMIA; DORSAL-ROOT GANGLIA; ACOUSTICALLY-RESPONSIVE SCAFFOLDS; DEVELOPING EXTERNAL GENITALIA; ANTI-FGF23 ANTIBODY KRN23;

D O I：

10.1002/wsbm.1549

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine kinases (FGFRs 1-4) and four intracellular proteins (intracellular FGFs or iFGFs) that primarily function to regulate the activity of voltage-gated sodium channels and other molecules. The canonical FGFs, endocrine FGFs, and iFGFs have been reviewed extensively by us and others. In this review, we briefly summarize past reviews and then focus on new developments in the FGF field since our last review in 2015. Some of the highlights in the past 6 years include the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, an expanded understanding of endocrine FGF signaling, functions for FGF signaling in stem cell pluripotency and differentiation, roles for FGF signaling in tissue homeostasis and regeneration, a continuing elaboration of mechanisms of FGF signaling in development, and an expanding appreciation of roles for FGF signaling in neuropsychiatric diseases. This article is categorized under: Cardiovascular Diseases > Molecular and Cellular Physiology Neurological Diseases > Molecular and Cellular Physiology Congenital Diseases > Stem Cells and Development Cancer > Stem Cells and Development

引用

页数：150

共 1533 条

[1] Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits [J].

Abrahao, Karina P. ;

Salinas, Armando G. ;

Lovinger, David M. .

NEURON, 2017, 96 (06) :1223-1238

[2]

Abu-Issa R, 2002, DEVELOPMENT, V129, P4613

[3] FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes [J].

Abu-Odeh, Mohammad ;

Zhang, Yuan ;

Reilly, Shannon M. ;

Ebadat, Nima ;

Keinan, Omer ;

Valentine, Joseph M. ;

Hafezi-Bakhtiari, Maziar ;

Ashayer, Hadeel ;

Mamoun, Lana ;

Zhou, Xin ;

Zhang, Jin ;

Yu, Ruth T. ;

Dai, Yang ;

Liddle, Christopher ;

Downes, Michael ;

Evans, Ronald M. ;

Kliewer, Steven A. ;

Mangelsdorf, David J. ;

Saltiel, Alan R. .

CELL REPORTS, 2021, 35 (13)

[4] MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development [J].

Achilleos, Annita ;

Huffman, Nichole T. ;

Marcinkiewicyz, Edwidge ;

Seidah, Nabil G. ;

Chen, Qian ;

Dallas, Sarah L. ;

Trainor, Paul A. ;

Gorski, Jeff P. .

HUMAN MOLECULAR GENETICS, 2015, 24 (10) :2884-2898

[5] FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism [J].

Acquaviva, Jaime ;

He, Suqin ;

Zhang, Chaohua ;

Jimenez, John-Paul ;

Nagai, Masazumi ;

Sang, Jim ;

Sequeira, Manuel ;

Smith, Donald L. ;

Ogawa, Luisa Shin ;

Inoue, Takayo ;

Tatsuta, Noriaki ;

Knowles, Margaret A. ;

Bates, Richard C. ;

Proia, David A. .

MOLECULAR CANCER RESEARCH, 2014, 12 (07) :1042-1054

[6] Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application [J].

Adachi, Tatsuo ;

Nakamura, Yoshikazu .

MOLECULES, 2019, 24 (23)

[7] Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth [J].

Adeyemo, Adeola ;

Johnson, Christopher ;

Stiene, Andrew ;

LaSance, Kathleen ;

Qi, Zhihua ;

Lemen, Lisa ;

Schultz, Jo El J. .

GROWTH FACTORS, 2020, 38 (02) :75-93

[8] Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development [J].

Agarwal, Megha ;

Sharma, Akashi ;

Kumar, Pankaj ;

Kumar, Amit ;

Bharadwaj, Anushree ;

Saini, Masum ;

Kardon, Gabrielle ;

Mathew, Sam J. .

DEVELOPMENT, 2020, 147 (07)

[9] Palatal and Oral Manifestations of Muenke Syndrome (FGFR3-Related Craniosynostosis) [J].

Agochukwu, Nneamaka Barbara ;

Solomon, Benjamin D. ;

Doherty, Emily S. ;

Muenke, Maximilian .

JOURNAL OF CRANIOFACIAL SURGERY, 2012, 23 (03) :664-668

[10] C-FGF23 peptide alleviates hypoferremia during acute inflammation [J].

Agoro, Rafiou ;

Park, Min Young ;

Henaff, Carole Le ;

Jankauskas, Stanislovas ;

Gaias, Alina ;

Chen, Gaozhi ;

Mohammadi, Moosa ;

Sitara, Despina .

HAEMATOLOGICA, 2021, 106 (02) :391-403

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