Pathogenesis of presbycusis in animal models: A review

被引：142

作者：

Fetoni, Anna R. ^{[1
]}

Picciotti, Pasqualina M. ^{[1
]}

Paludetti, Gaetano ^{[1
]}

Troiani, Diana ^{[2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Otolaryngol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Sch Med, Inst Human Physiol, I-00168 Rome, Italy

来源：

EXPERIMENTAL GERONTOLOGY | 2011年 / 46卷 / 06期

关键词：

ARHL; Hearing loss; Cochlea; Ageing; Stria vascularis; VEGF; SGNs; mDNA; ROS; INDUCED HEARING-LOSS; AGE-RELATED-CHANGES; OUTER HAIR CELL; CENTRAL AUDITORY-SYSTEM; MITOCHONDRIAL-DNA MUTATIONS; SPIRAL LIGAMENT PATHOLOGY; ENDOTHELIAL GROWTH-FACTOR; ESTROGEN-RECEPTOR-ALPHA; STRIA VASCULARIS; COCHLEAR DEGENERATION;

D O I：

10.1016/j.exger.2010.12.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills. Age related hearing loss can be defined as a progressive, bilateral, symmetrical hearing loss due to age related degeneration and it can be considered a multifactorial complex disorder, with both environmental and genetic factors contributing to the aetiology of the disease. The decline in hearing sensitivity caused by ageing is related to the damage at different levels of the auditory system (central and peripheral). Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory pathways. The mechanisms responsible for age-associated hearing loss are still incompletely characterized. This work aims to give a broad overview of the scientific findings related to presbycusis, focusing; mainly on experimental studies in animal models. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：413 / 425

页数：13

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