Characterization of Black Pigmenturia in a Cat with Apocrine Gland Cystadenocarcinoma

被引：1

作者：

Fournier, Q. ^{[1
]}

Hoehn, A. ^{[4
]}

Deubel, S. ^{[4
]}

Milne, E. ^{[2
,3
]}

Bavcar, S. ^{[1
]}

Morrison, L. ^{[2
,3
]}

机构：

[1] Univ Edinburgh, Hosp Small Anim, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, Easter Bush Pathol, Royal Dick Sch Vet Studies, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Roslin Inst, Edinburgh, Midlothian, Scotland

[4] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Toxicol, Arthur Scheunert Allee 111-116, Nuthetal, Germany

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2020年 / 176卷

关键词：

advanced glycation end-product; apocrine gland cystadenocarcinoma; cat; pigmenturia; GLYCATION END-PRODUCTS; LIPOFUSCIN; PENTOSIDINE; CATABOLISM; DISEASE; FATE;

D O I：

10.1016/j.jcpa.2020.03.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

An 8-year-old neutered female domestic shorthair cat was presented for further management of an apocrine gland cystadenocarcinoma. Extensive nodal metastasis was diagnosed and the cat was humanely destroyed 2 months after presentation. Post-mortem histopathology of the cystadenocarcinoma revealed areas of yellow-brown granular pigmentation on light microscopy, staining positively for reducing substances with Schmorl's stain and demonstrating autofluorescence on confocal microscopy. The cat's urine was black and also exhibited autofluorescence, and further analysis revealed increased free pentosidine. Based on these findings, it was presumed that the apocrine gland cystadenocarcinoma was producing lipofuscin-like pigments and that the characteristics of the urine were at least partially secondary to advanced glycation end-products. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：145 / 150

页数：6

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