Synthesis and quantitative evaluation of Glycero-D-manno-heptose binding to concanavalin a by fluorous-tag assistance

被引：73
作者：
Jaipuri, Firoz A. [2 ]
Collet, Beatrice Y. M. [2 ]
Pohl, Nicola L. [1 ]
机构：
[1] Iowa State Univ, Inst Plant Sci, Dept Chem, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Chem, Woden, ACT 2606, Australia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 09期
关键词：
biological activity; carbohydrates; fluorous synthesis; glycosides; microarrays;
D O I：
10.1002/anie.200704262
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Fooling conA? Fluorous microarrays allow not only qualitative, but also quantitative assessment of binding to show that conA can accept modifications to its usual mannose ligand at the C-6 position and bind to bacterial seven-carbon mannose analogues. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1707 / 1710
页数：4
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