Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis

被引：68
作者：
Weydt, P
Möller, T
机构：
[1] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Ctr Neurogenet & Neurotherapeut, Seattle, WA 98195 USA
来源：
NEUROREPORT | 2005年 / 16卷 / 06期
关键词：
amyotrophic lateral sclerosis; microglia; motor neuron; neuroinflammation; noncell autonomous;
D O I：
10.1097/00001756-200504250-00001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Annyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and annyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies. (c) 2005 Lippincott Williams& Wilkins.
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收藏
页码：527 / 531
页数：5
相关论文
共 39 条
  • [1] Immune reactivity in a mouse model of familial ALS correlates with disease progression
    Alexianu, ME
    Kozovska, M
    Appel, SH
    [J]. NEUROLOGY, 2001, 57 (07) : 1282 - 1289
  • [2] BROWN RH, 2000, AMYOTROPHIC LATERAL
  • [3] Unraveling the mechanisms involved in motor neuron degeneration in ALS
    Bruijn, LI
    Miller, TM
    Cleveland, DW
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2004, 27 : 723 - 749
  • [4] Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    Clement, AM
    Nguyen, MD
    Roberts, EA
    Garcia, ML
    Boillée, S
    Rule, M
    McMahon, AP
    Doucette, W
    Siwek, D
    Ferrante, RJ
    Brown, RH
    Julien, JP
    Goldstein, LSB
    Cleveland, DW
    [J]. SCIENCE, 2003, 302 (5642) : 113 - 117
  • [5] From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    Cleveland, DW
    Rothstein, JD
    [J]. NATURE REVIEWS NEUROSCIENCE, 2001, 2 (11) : 806 - 819
  • [6] CLEVELAND DW, 2004, 34 ANN M SOC NEUR SA
  • [7] Neuroinflammation, COX-2, and ALS - a dual role?
    Consilvio, C
    Vincent, AM
    Feldman, EL
    [J]. EXPERIMENTAL NEUROLOGY, 2004, 187 (01) : 1 - 10
  • [8] Neuroprotection by tetracyclines
    Domercq, M
    Matute, C
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (12) : 609 - 612
  • [9] Immune function of astrocytes
    Dong, YS
    Benveniste, EN
    [J]. GLIA, 2001, 36 (02) : 180 - 190
  • [10] Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
    Drachman, DB
    Frank, K
    Dykes-Hoberg, M
    Teismann, P
    Almer, G
    Przedborski, S
    Rothstein, JD
    [J]. ANNALS OF NEUROLOGY, 2002, 52 (06) : 771 - 778
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