Microfluidic Electrokinetic Preconcentration Chips: Enhancing the detection of nucleic acids and exosomes

被引：13

作者：

Kim, Jongmin ^{[1
]}

Sahloul, Sarah ^{[1
]}

Orozaliev, Ajymurat ^{[1
]}

Do, Vu Q. ^{[2
]}

Van Sang Pham ^{[2
]}

Martins, Diogo ^{[3
]}

Wei, Xi ^{[4
]}

Levicky, Rastislav ^{[5
]}

Song, Yong-Ak ^{[6
,7
]}

机构：

[1] New York Univ, Div Engn, Abu Dhabi, U Arab Emirates

[2] Hanoi Univ Sci & Technol, Sch Transportat Engn, Hanoi, Vietnam

[3] Univ Nova Lisboa, Fac Med Sci, NOVA Med Sch, Lisbon, Portugal

[4] Univ Sci & Technol China, Sch Comp Sci & Technol, Hefei, Peoples R China

[5] NYU, Dept Chem & Biomol Engn, Tandon Sch Engn, New York, NY USA

[6] New York Univ, Abu Dhabi, U Arab Emirates

[7] NYU, Dept Chem & Biomolec Ular Engn, Tandon Sch Engn, New York, NY USA

来源：

IEEE NANOTECHNOLOGY MAGAZINE | 2020年 / 14卷 / 02期

关键词：

Ions; Mathematical model; Electrokinetics; Computational modeling; DNA; Electric fields; Molecular biophysics; SOLID-PHASE EXTRACTION; CONCENTRATION POLARIZATION; SAMPLE STACKING; POROUS POLYMER; FREE DNA; SENSITIVITY; INTEGRATION; MICROARRAY; BIASES; ELECTROOSMOSIS;

D O I：

10.1109/MNANO.2020.2966064

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Over the past few years, the detection of biological analytes has intensively been studied to understand the biodiagnostics of various diseases [1]. Some of the analytes that have been used as biomarkers for specific diseases include cell-free nucleic acids, (for example, DNA), messenger RNA (mRNA) and microRNA (miRNA) [2]-[5], circulating tumor-specific nucleic acids [circulating tumor DNA (ctDNA) and ctRNA] [6]-[8], exosomes [9], [10], and circulating tumor cells [11]. These biomolecules are known to be effective indicators that can diagnose the presence of a potential disease even if their concentration changes slightly [12].

引用

页码：18 / 34

页数：17

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[21] Comparing whole genomes using DNA microarrays [J].