Acute Large Vessel Ischemic Stroke in Patients With COVID-19-Related Multisystem Inflammatory Syndrome

被引：12

作者：

Chang, Jaimie ^{[1
]}

Bulwa, Zachary ^{[1
]}

Breit, Hannah ^{[1
]}

Cherian, Laurel J. ^{[1
]}

Conners, James J. ^{[1
]}

Song, Sarah Y. ^{[1
]}

Dafer, Rima M. ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Dept Neurol, Chicago, IL 60612 USA

来源：

PEDIATRIC NEUROLOGY | 2022年 / 126卷

关键词：

Stroke; COVID-19; MIS-C; Acute ischemic infarction; Large vessel; SARS-Cov2; CHILDREN;

D O I：

10.1016/j.pediatrneurol.2021.09.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Acute ischemic stroke (AIS) is rare in children, and diagnosis is often delayed. Neurological involvement may occur in multisystem inflammatory syndrome in children (MIS-C), but very few cases of AIS in patients with MIS-C have been reported. Patient Descriptions: We two patients with AIS presenting with large vessel occlusive disease in previously healthy adolescents recently exposed to SARS-CoV-2 infection. Results: Both patients were subsequently diagnosed with and treated for MIS-C. Here, we discuss the course of their treatments and clinical responses. Conclusion: Early recognition and diagnosis of AIS with large vessel occlusion in children with MIS-C is critical to make available all treatment options to improve clinical outcomes. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：104 / 107

页数：4

共 16 条

[1]

American Academy of Pediatrics and the Children's Hospital Association, CHILDR COVID 19 STAT

[2] Arteritis and Large Vessel Occlusive Strokes in Children After COVID-19 Infection [J].

Appavu, Brian ;

Deng, Doris ;

Dowling, Michael Morgan ;

Garg, Shipra ;

Mangum, Tara ;

Boerwinkle, Varina ;

Abruzzo, Todd .

PEDIATRICS, 2021, 147 (03)

[3] Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2 [J].

Beslow, Lauren A. ;

Linds, Alexandra B. ;

Fox, Christine K. ;

Kossorotoff, Manoelle ;

Zuniga Zambrano, Yenny C. ;

Hernandez-Chavez, Marta ;

Hassanein, Sahar M. A. ;

Byrne, Susan ;

Lim, Ming ;

Maduaka, Nkechi ;

Zafeiriou, Dimitrios ;

Dowling, Michael M. ;

Felling, Ryan J. ;

Rafay, Mubeen F. ;

Lehman, Laura L. ;

Noetzel, Michael J. ;

Bernard, Timothy J. ;

Dlamini, Nomazulu .

ANNALS OF NEUROLOGY, 2021, 89 (04) :657-665

[4] The clinical features of 16 cases of stroke associated with administration of IVIg [J].

Caress, JB ;

Cartwright, MS ;

Donofrio, PD ;

Peacock, JE .

NEUROLOGY, 2003, 60 (11) :1822-1824

[5]

Centers for Disease Control and Prevention Health Alert Network (HAN), 2020, MULT INFL SYNDR CHIL

[6] Multisystem Inflammatory Syndrome in US Children and Adolescents [J].

Feldstein, Leora R. ;

Rose, Erica B. ;

Horwitz, Steven M. ;

Collins, Jennifer P. ;

Newhams, Margaret M. ;

Son, Mary Beth F. ;

Newburger, Jane W. ;

Kleinman, Lawrence C. ;

Heidemann, Sabrina M. ;

Martin, Amarilis A. ;

Singh, Aalok R. ;

Li, Simon ;

Tarquinio, Keiko M. ;

Jaggi, Preeti ;

Oster, Matthew E. ;

Zackai, Sheemon P. ;

Gillen, Jennifer ;

Ratner, Adam J. ;

Walsh, Rowan F. ;

Fitzgerald, Julie C. ;

Keenaghan, Michael A. ;

Alharash, Hussam ;

Doymaz, Sule ;

Clouser, Katharine N. ;

Giuliano, John S. ;

Gupta, Anjali ;

Parker, Robert M. ;

Maddux, Aline B. ;

Havalad, Vinod ;

Ramsingh, Stacy ;

Bukulmez, Hulya ;

Bradford, Tamara T. ;

Smith, Lincoln S. ;

Tenforde, Mark W. ;

Carroll, Christopher L. ;

Riggs, Becky J. ;

Gertz, Shira J. ;

Daube, Ariel ;

Lansell, Amanda ;

Coronado Munoz, Alvaro ;

Hobbs, Charlotte V. ;

Marohn, Kimberly L. ;

Halasa, Natasha B. ;

Patel, Manish M. ;

Randolph, Adrienne G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :334-346

[7] COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum [J].

Gaur, P. ;

Dixon, L. ;

Jones, B. ;

Lyall, H. ;

Jan, W. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2020, 41 (10) :1905-1907

[8] Vessel Wall Enhancement and Focal Cerebral Arteriopathy in a Pediatric Patient with Acute Infarct and COVID-19 Infection [J].

Gulko, E. ;

Overby, P. ;

Ali, S. ;

Mehta, H. ;

Al-Mufti, F. ;

Gomes, W. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2020, 41 (12) :2348-2350

[9] Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome [J].

LaRovere, Kerri L. ;

Riggs, Becky J. ;

Poussaint, Tina Y. ;

Young, Cameron C. ;

Newhams, Margaret M. ;

Maamari, Mia ;

Walker, Tracie C. ;

Singh, Aalok R. ;

Dapul, Heda ;

Hobbs, Charlotte V. ;

McLaughlin, Gwenn E. ;

Son, Mary Beth F. ;

Maddux, Aline B. ;

Clouser, Katharine N. ;

Rowan, Courtney M. ;

McGuire, John K. ;

Fitzgerald, Julie C. ;

Gertz, Shira J. ;

Shein, Steven L. ;

Munoz, Alvaro Coronado ;

Thomas, Neal J. ;

Irby, Katherine ;

Levy, Emily R. ;

Staat, Mary A. ;

Tenforde, Mark W. ;

Feldstein, Leora R. ;

Halasa, Natasha B. ;

Giuliano, John S., Jr. ;

Hall, Mark W. ;

Kong, Michele ;

Carroll, Christopher L. ;

Schuster, Jennifer E. ;

Doymaz, Sule ;

Loftis, Laura L. ;

Tarquinio, Keiko M. ;

Babbitt, Christopher J. ;

Nofziger, Ryan A. ;

Kleinman, Lawrence C. ;

Keenaghan, Michael A. ;

Cvijanovich, Natalie Z. ;

Spinella, Philip C. ;

Hume, Janet R. ;

Wellnitz, Kari ;

Mack, Elizabeth H. ;

Michelson, Kelly N. ;

Flori, Heidi R. ;

Patel, Manish M. ;

Randolph, Adrienne G. .

JAMA NEUROLOGY, 2021, 78 (05) :536-547

[10] The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) [J].

Mavrogeni, Sophie I. ;

Kolovou, Genovefa ;

Tsirimpis, Vasileios ;

Kafetzis, Dimitrios ;

Tsolas, Georgios ;

Fotis, Lampros .

RHEUMATOLOGY INTERNATIONAL, 2021, 41 (06) :1037-1044

← 1 2 →