Statin therapy for primary prevention in women: What is the role for coronary artery calcium?

被引：2

作者：

Grundy, Scott M. ^{[1
]}

Vega, Gloria Lena

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Ctr Human Nutr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2022年 / 16卷 / 04期

关键词：

Coronary artery calcium score; Women; Statins; HEART-DISEASE EVENTS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BLOOD CHOLESTEROL; AMERICAN-COLLEGE; 000; PARTICIPANTS; RISK; ASSOCIATION; GUIDELINES; METAANALYSIS;

D O I：

10.1016/j.jacl.2022.05.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

By current guidelines, statin treatment decisions depend on multiple risk factor algorithms (e.g., pooled cohort equations [PCEs]). By available PCEs most older middle-aged women are statin eligible. But several studies cast doubt on reliability of available PCEs for ASCVD risk assessment. An alternative method for risk assessment is a coronary artery calcium (CAC) score. Many older women have zero CAC, which equates to low risk for ASCVD; these women can delay statin therapy for several years before re-scanning. When CAC is 1-99 Agatston units, risk is only borderline high and statin delay also is an option until re-scanning. When CAC is > 100 Agatston units, risk is high enough to warrant a statin. In most women, CAC is the best guide to treatment decisions. In high-risk women (e.g., diabetes and severe hypercholesterolemia), generally are indicated, but CAC can assist in risk assessment, but other risk factors also can aid in treatment decisions. (C) 2022 National Lipid Association. Published by Elsevier Inc.

引用

页码：376 / 382

页数：7

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