STEAROYL LYSOPHOSPHATIDYLCHOLINE INHIBITS ENDOTOXIN-INDUCED CASPASE-11 ACTIVATION

被引：29

作者：

Li, Wenbo ^{[1
,2
]}

Zhang, Wei ^{[3
,6
]}

Deng, Meihong ^{[2
]}

Loughran, Patricia ^{[5
]}

Tang, Yiting ^{[4
]}

Liao, Hong ^{[2
]}

Zhang, Xianying ^{[7
,8
]}

Liu, Jian ^{[7
,8
]}

Billiar, Timothy R. ^{[1
,2
]}

Lu, Ben ^{[4
,7
,8
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Dept Surg, Changsha, Hunan, Peoples R China

[2] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA

[3] Hunan Inst Drug Control, Changsha, Hunan, Peoples R China

[4] Cent South Univ, State Key Lab Med Genet, Sch Biol Sci & Technol, Changsha, Hunan, Peoples R China

[5] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA USA

[6] Cent South Univ, Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China

[7] Cent South Univ, Dept Hematol, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

[8] Cent South Univ, Inst Infect & Computat Med, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

来源：

SHOCK | 2018年 / 50卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Innate immunity; non-canonical inflammasome; endotoxemia; pyroptosis; NONCANONICAL INFLAMMASOME ACTIVATION; LPS; ATHEROSCLEROSIS; REQUIRES; RELEASE; SEPSIS;

D O I：

10.1097/SHK.0000000000001012

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Stearoyl lysophosphatidylcholine (LPC) exerts protective effect during endotoxemia and in experimental sepsis, but the underlying mechanism is unclear. Here, we demonstrated that stearoyl LPC could block caspase-11mediated macrophage pyroptosis. In vitro, stearoyl LPC significantly decreased caspase-11 activation and pyroptosis induced by lipopolysaccharide (LPS) plus cholera toxin subunit B independent of the receptor G2A. Stearoyl LPC did not affect LPS uptake by mouse peritoneal macrophages but did significantly inhibit the interaction between LPS and caspase11. Moreover, stearoyl LPC treatment conferred significant protection against lethal endotoxemia and significantly reduced the release of IL-1 alpha and IL-1 beta. These findings identify stearoyl LPC as an inhibitor of LPS-mediated caspase-11 activation. This mechanism could explain the protective action of stearoyl LPC in experimental sepsis and endotoxemia.

引用

页码：339 / 345

页数：7

共 26 条

[21] ROLE OF OXIDATIVELY MODIFIED LDL IN ATHEROSCLEROSIS
STEINBRECHER, UP
ZHANG, HF
LOUGHEED, M
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1990, 9 (02) : 155 - 168
[22] Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation
Vanaja, Sivapriya Kailasan
Russo, Ashley J.
Behl, Bharat
Banerjee, Ishita
Yankova, Maya
Deshmukh, Sachin D.
Rathinam, Vijay A. K.
[J]. CELL, 2016, 165 (05) : 1106 - 1119
[23] Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
von Moltke, Jakob
Trinidad, Norver J.
Moayeri, Mahtab
Kintzer, Alexander F.
Wang, Samantha B.
van Rooijen, Nico
Brown, Charles R.
Krantz, Bryan A.
Leppla, Stephen H.
Gronert, Karsten
Vance, Russell E.
[J]. NATURE, 2012, 490 (7418) : 107 - U126
[24] Therapeutic effects of lysophosphatidylcholine in experimental sepsis
Yan, JJ
Jung, JS
Lee, JE
Lee, J
Huh, SO
Kim, HS
Jung, KC
Cho, JY
Nam, JS
Suh, HW
Kim, YH
Song, DK
[J]. NATURE MEDICINE, 2004, 10 (02) : 161 - 167
[25] Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock
Yang, Dahai
He, Yuan
Munoz-Planillo, Raul
Liu, Qin
Nunez, Gabriel
[J]. IMMUNITY, 2015, 43 (05) : 923 - 932
[26] An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Zanoni, Ivan
Tan, Yunhao
Di Gioia, Marco
Broggi, Achille
Ruan, Jianbin
Shi, Jianjin
Donado, Carlos A.
Shao, Feng
Wu, Hao
Springstead, James R.
Kagan, Jonathan C.
[J]. SCIENCE, 2016, 352 (6290) : 1232 - 1236

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