Synthesis and biological evaluation of novel n-[3-(4-phenylpip-erazin-1-yl)-propyl]-carboxamide derivatives

被引：2

作者：

Weng, Zhiyong ^{[1
]}

Gao, Yanping ^{[1
]}

Zhang, Jiankang ^{[1
]}

Dong, Xiaowu ^{[1
]}

Liu, Tao ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2011年 / 01期

基金：

中国国家自然科学基金;

关键词：

N-[3-(4-phenylpiperazin-1-yl)-propyl]-carboxamide; HIV; cell-cell fusion assays; SMALL-MOLECULE CCR5; ANTAGONIST; TAK-220;

D O I：

10.3184/174751911X556828

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel N-[3-(4-phenylpiperazin-1-yl)-propyl]-carboxamide derivatives were synthesised and studied for the potential treatment of HIV. These compounds were obtained through the efficient synthetic route that involved microwave assisted synthesis. These new compounds have been characterised by IR, (1)H NMR, MS and elemental analysis. The cell-cell fusion inhibitory activities of the compounds have also been evaluated.

引用

页码：43 / 46

页数：4

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