Hippo signalling in intestinal regeneration and cancer

被引：52

作者：

Gregorieff, Alex ^{[1
,3
,4
]}

Wrana, Jeffrey L. ^{[1
,2
]}

机构：

[1] Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[3] McGill Univ, Dept Pathol, Montreal, PQ, Canada

[4] McGill Univ, Ctr Hlth, Res Inst, Canc Res Program, Montreal, PQ, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 2017年 / 48卷

关键词：

STEM-CELL NICHE; BETA-CATENIN; TGF-BETA; WNT/BETA-CATENIN; PROSTAGLANDIN E-2; EPITHELIAL-CELLS; GENE-EXPRESSION; SELF-RENEWAL; APC LOSS; PATHWAY;

D O I：

10.1016/j.ceb.2017.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Hippo pathway is a unique signalling module that regulates cell-specific transcriptional responses and responds to a wide range of intrinsic and extrinsic cues. Besides its classical role in restricting tissue size during development, Hippo signalling is now recognized to control numerous processes including cell proliferation, survival, cell fate determination, epithelial-to-mesenchymal transitions and cell migration. Because of its highly dynamic nature, the intestinal epithelium has served as an exceptional model to study the complex roles of Hippo signalling. In this review, we shall present an overview of Hippo function in the mammalian intestine and discuss the various mechanisms regulating Hippo signalling and how they contribute to intestinal regeneration and cancer.

引用

页码：17 / 25

页数：9

共 90 条

[1] Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine [J].

Andreu, P ;

Colnot, S ;

Godard, C ;

Gad, S ;

Chafey, P ;

Niwa-Kawakita, M ;

Laurent-Puig, P ;

Kahn, A ;

Robine, S ;

Perret, C ;

Romagnolo, B .

DEVELOPMENT, 2005, 132 (06) :1443-1451

[2] YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response [J].

Azzolin, Luca ;

Panciera, Tito ;

Soligo, Sandra ;

Enzo, Elena ;

Bicciato, Silvio ;

Dupont, Sirio ;

Bresolin, Silvia ;

Frasson, Chiara ;

Basso, Giuseppe ;

Guzzardo, Vincenza ;

Fassina, Ambrogio ;

Cordenonsi, Michelangelo ;

Piccolo, Stefano .

CELL, 2014, 158 (01) :157-170

[3] Role of TAZ as Mediator of Wnt Signaling [J].

Azzolin, Luca ;

Zanconato, Francesca ;

Bresolin, Silvia ;

Forcato, Mattia ;

Basso, Giuseppe ;

Bicciato, Silvio ;

Cordenonsi, Michelangelo ;

Piccolo, Stefano .

CELL, 2012, 151 (07) :1443-1456

[4] Restriction of intestinal stem cell expansion and the regenerative response by YAP [J].

Barry, Evan R. ;

Morikawa, Teppei ;

Butler, Brian L. ;

Shrestha, Kriti ;

de la Rosa, Rosemarie ;

Yan, Kelley S. ;

Fuchs, Charles S. ;

Magness, Scott T. ;

Smits, Ron ;

Ogino, Shuji ;

Kuo, Calvin J. ;

Camargo, Fernando D. .

NATURE, 2013, 493 (7430) :106-+

[5] Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension [J].

Bertero, Thomas ;

Oldham, William M. ;

Cottrill, Katherine A. ;

Pisano, Sabrina ;

Vanderpool, Rebecca R. ;

Yu, Qiujun ;

Zhao, Jingsi ;

Tai, Yiyin ;

Tang, Ying ;

Zhang, Ying-Yi ;

Rehman, Sofiya ;

Sugahara, Masataka ;

Qi, Zhi ;

Gorcsan, John, III ;

Vargas, Sara O. ;

Saggar, Rajan ;

Saggar, Rajeev ;

Wallace, W. Dean ;

Ross, David J. ;

Haley, Kathleen J. ;

Waxman, Aaron B. ;

Parikh, Victoria N. ;

De Marco, Teresa ;

Hsue, Priscilla Y. ;

Morris, Alison ;

Simon, Marc A. ;

Norris, Karen A. ;

Gaggioli, Cedric ;

Loscalzo, Joseph ;

Fessel, Joshua ;

Chan, Stephen Y. .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (09) :3313-3335

[6] Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells [J].

Beyer, Tobias A. ;

Weiss, Alexander ;

Khomchuk, Yuliya ;

Huang, Kui ;

Ogunjimi, Abiodun A. ;

Varelas, Xaralabos ;

Wrana, Jeffrey L. .

CELL REPORTS, 2013, 5 (06) :1611-1624

[7] Microenvironmental control of stem cell fate in intestinal homeostasis and disease [J].

Biswas, Sujata ;

Davis, Hayley ;

Irshad, Shazia ;

Sandberg, Tessa ;

Worthley, Daniel ;

Leedham, Simon .

JOURNAL OF PATHOLOGY, 2015, 237 (02) :135-145

[8] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].

Bollrath, Julia ;

Phesse, Toby J. ;

von Burstin, Vivian A. ;

Putoczki, Tracy ;

Bennecke, Moritz ;

Bateman, Trudie ;

Nebelsiek, Tim ;

Lundgren-May, Therese ;

Canli, Oezge ;

Schwitalla, Sarah ;

Matthews, Vance ;

Schmid, Roland M. ;

Kirchner, Thomas ;

Arkan, Melek C. ;

Ernst, Matthias ;

Greten, Florian R. .

CANCER CELL, 2009, 15 (02) :91-102

[9] β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis [J].

Cai, Jing ;

Maitra, Anirban ;

Anders, Robert A. ;

Taketo, Makoto M. ;

Pan, Duojia .

GENES & DEVELOPMENT, 2015, 29 (14) :1493-1506

[10] The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program [J].

Cai, Jing ;

Zhang, Nailing ;

Zheng, Yonggang ;

de Wilde, Roeland F. ;

Maitra, Anirban ;

Pan, Duojia .

GENES & DEVELOPMENT, 2010, 24 (21) :2383-2388

← 1 2 3 4 5 6 7 8 9 →