Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

被引：35
作者：
Cheignon, Clemence [1 ,2 ,3 ,4 ]
Collin, Fabrice [1 ,2 ,3 ,4 ]
Faller, Peter [1 ,2 ,3 ]
Hureau, Christelle [1 ,2 ,3 ]
机构：
[1] CNRS UPR 8241, LCC, 205 Route Narbonne, F-31062 Toulouse 09, France
[2] Univ Toulouse, F-31077 Toulouse, France
[3] UPS, INPT, F-31077 Toulouse, France
[4] Univ Toulouse, UPS, IRD, UMR Pharma Dev 152, Toulouse, France
来源：
DALTON TRANSACTIONS | 2016年 / 45卷 / 32期
基金：
欧洲研究理事会;
关键词：
AMYLOID-BETA; ROS PRODUCTION; COPPER; COORDINATION; CU; DEPOLARIZATION; PROOXIDANT; RELEASE; BRAIN;
D O I：
10.1039/c6dt01979j
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(A beta) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-beta peptide itself.
引用
收藏
页码：12627 / 12631
页数：5
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