Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

被引：35
作者：
Cheignon, Clemence [1 ,2 ,3 ,4 ]
Collin, Fabrice [1 ,2 ,3 ,4 ]
Faller, Peter [1 ,2 ,3 ]
Hureau, Christelle [1 ,2 ,3 ]
机构：
[1] CNRS UPR 8241, LCC, 205 Route Narbonne, F-31062 Toulouse 09, France
[2] Univ Toulouse, F-31077 Toulouse, France
[3] UPS, INPT, F-31077 Toulouse, France
[4] Univ Toulouse, UPS, IRD, UMR Pharma Dev 152, Toulouse, France
来源：
DALTON TRANSACTIONS | 2016年 / 45卷 / 32期
基金：
欧洲研究理事会;
关键词：
AMYLOID-BETA; ROS PRODUCTION; COPPER; COORDINATION; CU; DEPOLARIZATION; PROOXIDANT; RELEASE; BRAIN;
D O I：
10.1039/c6dt01979j
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(A beta) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-beta peptide itself.
引用
收藏
页码：12627 / 12631
页数：5
相关论文
共 33 条
[1]   Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity [J].
Alies, Bruno ;
Sasaki, Isabelle ;
Proux, Olivier ;
Sayen, Stephanie ;
Guillon, Emmanuel ;
Faller, Peter ;
Hureau, Christelle .
CHEMICAL COMMUNICATIONS, 2013, 49 (12) :1214-1216
[2]   Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand [J].
Atrian-Blasco, E. ;
Cerrada, E. ;
Conte-Daban, A. ;
Testemale, D. ;
Faller, P. ;
Laguna, M. ;
Hureau, C. .
METALLOMICS, 2015, 7 (08) :1229-1232
[3]   Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-β copper complex follow a preorganization mechanism [J].
Balland, Veronique ;
Hureau, Christelle ;
Saveant, Jean-Michel .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (40) :17113-17118
[4]   Biological metals and metal-targeting compounds in major neurodegenerative diseases [J].
Barnham, Kevin J. ;
Bush, Ashley I. .
CHEMICAL SOCIETY REVIEWS, 2014, 43 (19) :6727-6749
[5]   SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways [J].
Batinic-Haberle, Ines ;
Tovmasyan, Artak ;
Roberts, Emily R. H. ;
Vujaskovic, Zeljko ;
Leong, Kam W. ;
Spasojevic, Ivan .
ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (15) :2372-2415
[6]   Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential [J].
Batinic-Haberle, Ines ;
Reboucas, Julio S. ;
Spasojevic, Ivan .
ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (06) :877-918
[7]   Oxidative stress in Alzheimer disease: A possibility for prevention [J].
Bonda, David J. ;
Wang, Xinglong ;
Perry, George ;
Nunomura, Akihiko ;
Tabaton, Massimo ;
Zhu, Xiongwei ;
Smith, Mark A. .
NEUROPHARMACOLOGY, 2010, 59 (4-5) :290-294
[8]   Catalytic metals, ascorbate and free radicals: Combinations to avoid [J].
Buettner, GR ;
Jurkiewicz, BA .
RADIATION RESEARCH, 1996, 145 (05) :532-541
[9]   Does vitamin C act as a pro-oxidant under physiological conditions? [J].
Carr, A ;
Frei, B .
FASEB JOURNAL, 1999, 13 (09) :1007-1024
[10]   The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production [J].
Cassagnes, Laure-Estelle ;
Herve, Vincent ;
Nepveu, Francoise ;
Hureau, Christelle ;
Faller, Peter ;
Collin, Fabrice .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (42) :11110-11113
1234