Case 37-2021: A 60-Year-Old Man with Fevers, Fatigue, Arthralgias, a Mouth Ulcer, and a Rash

被引：1

作者：

Wallace, Zachary S. ^{[1
,4
]}

Rodriguez, Karen ^{[2
,5
]}

Dau, Jonathan ^{[1
,4
]}

Bloch, Donald B. ^{[1
,4
]}

Champion, Samantha N. ^{[3
,6
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[4] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[5] Harvard Med Sch, Dept Radiol, Boston, MA 02115 USA

[6] Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 24期

关键词：

DERMATOMYOSITIS;

D O I：

10.1056/NEJMcpc2107353

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A Man with Fevers, Fatigue, Arthralgias, a Mouth Ulcer, and a Rash A 60-year-old man presented with ongoing fevers and fatigue, a tongue ulcer, dry scaly nodules on the face and hands, and migratory arthralgias in the wrists, fingers, elbows, and shoulders. CT revealed dependent reticular opacities throughout the lower lobes of the lungs. Hypoxemia developed. A diagnostic test was performed.

引用

页码：2282 / 2293

页数：12

共 19 条

[1] Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5 [J].

Brisse, Morgan ;

Ly, Hinh .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[2] Re-examining mechanic's hands as a characteristic skin finding in dermatomyositis [J].

Concha, Josef Symon S. ;

Merola, Joseph F. ;

Fiorentino, David ;

Werth, Victoria P. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (04) :769-+

[3] Inclusion Body Myositis [J].

Dimachkie, Mazen M. ;

Barohn, Richard J. .

NEUROLOGIC CLINICS, 2014, 32 (03) :629-+

[4] Mechanisms, biomarkers and targets for adult-onset Still's disease [J].

Feist, Eugen ;

Mitrovic, Stephane ;

Fautrel, Bruno .

NATURE REVIEWS RHEUMATOLOGY, 2018, 14 (10) :603-618

[5] ANCA are detectable in nearly all patients with active severe Wegener's granulomatosis [J].

Finkielman, Javier D. ;

Lee, Augustine S. ;

Hummel, Amber M. ;

Viss, Margaret A. ;

Jacob, Gregory L. ;

Homburger, Henry A. ;

Peikert, Tobias ;

Hoffman, Gary S. ;

Merkel, Peter A. ;

Spiera, Robert ;

St. Clair, E. William ;

Davis, John C., Jr. ;

McCune, W. Joseph ;

Tibbs, Andrea K. ;

Ytterberg, Steven R. ;

Stone, John H. ;

Specks, Ulrich .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (07) :643.e9-643.e14

[6] Clinical spectrum and therapeutics in Canadian patients with anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis: a case-based review [J].

Huang, Kun ;

Vinik, Ophir ;

Shojania, Kam ;

Yeung, James ;

Shupak, Rachel ;

Nimmo, Michael ;

Avina-Zubieta, J. Antonio .

RHEUMATOLOGY INTERNATIONAL, 2019, 39 (11) :1971-1981

[7] 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides [J].

Jennette, J. C. ;

Falk, R. J. ;

Bacon, P. A. ;

Basu, N. ;

Cid, M. C. ;

Ferrario, F. ;

Flores-Suarez, L. F. ;

Gross, W. L. ;

Guillevin, L. ;

Hagen, E. C. ;

Hoffman, G. S. ;

Jayne, D. R. ;

Kallenberg, C. G. M. ;

Lamprecht, P. ;

Langford, C. A. ;

Luqmani, R. A. ;

Mahr, A. D. ;

Matteson, E. L. ;

Merkel, P. A. ;

Ozen, S. ;

Pusey, C. D. ;

Rasmussen, N. ;

Rees, A. J. ;

Scott, D. G. I. ;

Specks, U. ;

Stone, J. H. ;

Takahashi, K. ;

Watts, R. A. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (01) :1-11

[8] Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis [J].

Kurasawa, Kazuhiro ;

Arai, Satoko ;

Namiki, Yumeko ;

Tanaka, Ayae ;

Takamura, Yuta ;

Owada, Takayoshi ;

Arima, Masafumi ;

Maezawa, Reika .

RHEUMATOLOGY, 2018, 57 (12) :2114-2119

[9] Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features [J].

Kurtzman, Drew J. B. ;

Vleugels, Ruth Ann .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 78 (04) :776-785

[10] Systemic lupus erythematosus [J].

Lisnevskaia, Larissa ;

Murphy, Grainne ;

Isenberg, David .

LANCET, 2014, 384 (9957) :1878-1888

← 1 2 →