Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata

被引：33
作者：
Wang, Juan [1 ,2 ]
Wang, Xiao-Hui [1 ]
Liu, Xiao [1 ]
Li, Jun [1 ]
Shi, Xiao-Ping [1 ,2 ]
Song, Yue-Lin [1 ]
Zeng, Ke-Wu [3 ]
Zhang, Le [1 ,2 ]
Tu, Peng-Fei [1 ]
Shi, She-Po [1 ]
机构：
[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 15期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
CHAIN-LENGTH CONTROL; BENZALACETONE SYNTHASE; PYRAZOLE DERIVATIVES; PENTAKETIDE CHROMONE; EFFICIENT SYNTHESIS; CHALCONE SYNTHASE; RHEUM-PALMATUM; BOND FORMATION; ORYZA-SATIVA; BIOSYNTHESIS;
D O I：
10.1021/acs.orglett.6b01501
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
引用
收藏
页码：3550 / 3553
页数：4
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