CD8+ T cells in inflammatory demyelinating disease

被引：42

作者：

Weiss, Hanne A.

Millward, Jason A.

Owens, Trevor

机构：

[1] Univ So Denmark, Ctr Med Biotechnol, DK-5000 Odense C, Denmark

[2] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 191卷 / 1-2期

关键词：

CD8; interferon-gamma; interleukin-17; MS; EAE; T cells;

D O I：

10.1016/j.jneuroim.2007.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We review the contribution made by CD8(+) T cells to inflammation in the central nervous system (CNS) in Multiple Sclerosis (MS), and discuss their role in the animal model Experimental Autoimmune Encephalomyelitis (EAE). We show that the inflammatory cytokines interferon-gamma and interleukin-17 are differentially regulated in CNS-infiltrating CD4(+) and CD8(+) T cells in EAE, and that CD8(+) T cells regulate disease. In MS, CD8(+) T cells appear to play a role in promotion of disease, so cytokine regulation is likely different in CD8(+) T cells in MS and EAE. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：79 / 85

页数：7

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