The emerging role of long non-coding RNAs in the drug resistance of colorectal cancer

被引：2

作者：

Chen, Dong-Liang ^{[1
]}

Xu, Rui-Hua ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, 651 Dong Feng East Rd, Guangzhou, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2018年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

CRC; lncRNA; drug resistance; OXALIPLATIN-BASED CHEMOTHERAPY; MOLECULAR-MECHANISMS; METASTATIC PROGRESSION; CISPLATIN RESISTANCE; MULTIDRUG-RESISTANCE; DECREASED EXPRESSION; SIGNALING PATHWAY; DOWN-REGULATION; CETUXIMAB; FLUOROURACIL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths in the world. Chemotherapy has been used to treat CRC patients in order to improve prognosis. Oxaliplatin and 5-Fluorouracil (5-FU) based chemotherapy is a first line treatment for locally advanced and metastatic CRC. For patients with wild-type KRAS metastatic CRC, cetuximab (an EGFR monoclonal antibody) is a commonly used targeted therapy. CRC is initially sensitive to chemotherapy and targeted therapy. However, drug resistance frequently arises, which significantly affect the treatment outcome in these patients. An increasing number of studies have indicated that lncRNAs are implicated in the drug resistance of CRC. This review aims to gain insights into the role and molecular mechanism of lncRNAs in CRC drug resistance.

引用

页码：4735 / 4743

页数：9

共 70 条

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