One-Pot Thioether Formation from S-Nitrosothiols

被引：14

作者：

Zhang, Dehui ^{[1
]}

Devarie-Baez, Nelmi O. ^{[1
]}

Pan, Jia ^{[1
]}

Wang, Hua ^{[1
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 24期

基金：

美国国家科学基金会;

关键词：

REDUCTIVE LIGATION; NITROSATION; NITROSYLATION;

D O I：

10.1021/ol102491n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.

引用

页码：5674 / 5676

页数：3

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