Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch

被引：68
作者：
Zhu, Shenmin
Zhou, Zhengyang
Zhang, Di
Jin, Chan
Li, Zhiqiang
机构：
[1] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200030, Peoples R China
[2] Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2007年 / 106卷 / 1-3期
基金：
中国国家自然科学基金;
关键词：
SBA-15; controlled release; PNIPA; IBU;
D O I：
10.1016/j.micromeso.2007.02.027
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel responsive carrier system based on ordered mesoporous silica SBA-15 was synthesized, with magnetic particles formed in situ and thermo-sensitive poly(N-isopropyl acrylamide) (PNIPA) polymerized inside the pores. It was interesting to find that the obtained system held a relatively large pore diameter (3.8 nm) and pore volume (0.47 cm(3) g(-1)), which would benefit for drug storage with relatively large molecules. The delivery system displayed a hysteresis loop with a saturation magnetization (M-s) of 0.40 emu/g, which revealed the magnetic property of the prepared system. In vitro test of ibuprofen (IBU) loading and release exhibited a pronounced transition at around 17 degrees C, indicating a typical thermo-sensitive release property for this delivery system. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：56 / 61
页数：6
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