miR-29b inhibits non-small cell lung cancer progression by targeting STRN4

被引:20
作者
Xie, Yuping [1 ]
Zhao, Fen [1 ]
Zhang, Ping [1 ]
Duan, Ping [1 ]
Shen, Yangmei [1 ,2 ]
机构
[1] Chengdu City First People's Hosp, Dept Oncology, Chengdu, Peoples R China
[2] w China Second Univ Hosp, Sichuan Univ, Dept Pathology, Chengdu, Peoples R China
关键词
miR-29b; STRN4; Non-small cell lung cancer; Progression; Overexpression; CALMODULIN-BINDING PROTEIN; STRIATIN; FAMILY; EXPRESSION; MICRORNAS; APOPTOSIS; MIGRATION; INVASION; STRIPAK; KINASE;
D O I
10.1007/s13577-019-00305-w
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Non-small cell lung cancer (NSCLC) is a malignant tumor with a high fatality, low overall cure, and survival rates worldwide. When only palliative therapy is available, the disease leads to malignant proliferation. Previous studies showed miR-29b serves as an NSCLC suppressor by inhibiting cells proliferation, migration, and invasion. However, the mechanism underlying NSCLC progression remains elusive. In this study, we identified Striatin 4 (STRN4), a target of miR-29b, which serves as a pro-oncogenic protein by promoting cells proliferation, migration, and invasion in NSCLC. Besides, the STRN4 was highly expressed in NSCLC and negatively regulated by miR-29b. Down-regulation of STRN4 inhibits NSCLC cells proliferation, migration, invasion, and promotes apoptosis in vitro, whereas overexpression-induced enhanced cell migration and invasion could be reverved by miR-29b. Notably, overexpression of miR-29b and down-regulation of STRN4 by shRNA suppressed cellular proliferation and delayed tumor progression in vivo. Together, these findings identify a miR-29b/STRN4 regulatory pathway in NSCLC progression, which may provide a new sight for the treatment of NSCLC.
引用
收藏
页码:220 / 231
页数:12
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