Mechanisms regulating epithelial stratification

被引：238
作者：
Koster, Maranke I. [1 ]
Roop, Dennis R. [1 ]
机构：
[1] Univ Colorado Denver, Ctr Hearing Sci, Dept Dermatol, Charles C Gate Program Regenerap Med & Stem Cell, Aurora, CO 80010 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2007年 / 23卷
关键词：
epidermal morphogenesis; barrier formation; p63;
D O I：
10.1146/annurev.cellbio.23.090506.123357
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphological changes that occur during epidermal development have been extensively studied, the molecular mechanisms that govern this process remain poorly understood. In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis.
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页码：93 / 113
页数：21
相关论文
共 132 条
  • [121] Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia
    Uyttendaele, H
    Panteleyev, AA
    de Berker, D
    Tobin, DJ
    Christiano, AM
    [J]. DIFFERENTIATION, 2004, 72 (08) : 396 - 409
  • [122] Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE
    Vooijs, Marc
    Ong, Chin-Tong
    Hadland, Brandon
    Huppert, Stacey
    Liu, Zhenyi
    Korving, Jeroen
    van den Born, Maaike
    Stappenbeck, Thaddeus
    Wu, Yumei
    Clevers, Hans
    Kopan, Raphael
    [J]. DEVELOPMENT, 2007, 134 (03): : 535 - 544
  • [123] Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    Wakabayashi, N
    Itoh, K
    Wakabayashi, J
    Motohashi, H
    Noda, S
    Takahashi, S
    Imakado, S
    Kotsuji, T
    Otsuka, F
    Roop, DR
    Harada, T
    Engel, JD
    Yamamoto, M
    [J]. NATURE GENETICS, 2003, 35 (03) : 238 - 245
  • [124] WEISS LW, 1975, ACTA DERM-VENEREOL, V55, P321
  • [125] The ΔNp63α phosphoprotein binds the p21 and 14-3-3σ promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
    Westfall, MD
    Mays, DJ
    Sniezek, JC
    Pietenpol, JA
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (07) : 2264 - 2276
  • [126] INDUCTION OF EPIDERMIS AND INHIBITION OF NEURAL FATE BY BMP-4
    WILSON, PA
    HEMMATIBRIVANLOU, A
    [J]. NATURE, 1995, 376 (6538) : 331 - 333
  • [127] The status of Wnt signalling regulates neural and epidermal fates in the chick embryo
    Wilson, SI
    Rydström, A
    Trimborn, T
    Willert, K
    Nusse, R
    Jessell, TM
    Edlund, T
    [J]. NATURE, 2001, 411 (6835) : 325 - 330
  • [128] p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    Yang, A
    Schweitzer, R
    Sun, DQ
    Kaghad, M
    Walker, N
    Bronson, RT
    Tabin, C
    Sharpe, A
    Caput, D
    Crum, C
    McKeon, F
    [J]. NATURE, 1999, 398 (6729) : 714 - 718
  • [129] Role of protein kinase C α in calcium induced keratinocyte differentiation:: Defective regulation in squamous cell carcinoma
    Yang, LC
    Ng, DC
    Bikle, DD
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (02) : 249 - 259
  • [130] Cloning and expression of the chick p63 gene
    Yasue, A
    Tao, H
    Nohno, T
    Moriyama, K
    Noji, S
    Ohuchi, H
    [J]. MECHANISMS OF DEVELOPMENT, 2001, 100 (01) : 105 - 108
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