Mechanisms regulating epithelial stratification

被引：243
作者：
Koster, Maranke I. [1 ]
Roop, Dennis R. [1 ]
机构：
[1] Univ Colorado Denver, Ctr Hearing Sci, Dept Dermatol, Charles C Gate Program Regenerap Med & Stem Cell, Aurora, CO 80010 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2007年 / 23卷
关键词：
epidermal morphogenesis; barrier formation; p63;
D O I：
10.1146/annurev.cellbio.23.090506.123357
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The epidermis is a stratified epithelium that functions as a barrier protecting the organism from dehydration, mechanical trauma, and microbial insults. This barrier function is established during embryogenesis through a complex and tightly controlled stratification program. Whereas the morphological changes that occur during epidermal development have been extensively studied, the molecular mechanisms that govern this process remain poorly understood. In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis.
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页码：93 / 113
页数：21
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